A Review of Deep Learning Approaches for Early Diagnosis of Alzheimer's Disease

Alzheimer's disease (AD), one of the major neurodegenerative diseases, has become the most common cause of dementia problems. Up to now, there is a lack of effective targeted therapeutic drugs and effective treatment modalities to stop the progression of the disease. With the continuous development of computer technology, the use of computer-aided diagnostic technology tools for AD early classification studies will provide clinicians with important assistance. Deep learning-based Alzheimer's disease (AD) imaging classification has become a current research hotspot. In this paper, we first describe the commonly used publicly available datasets in the AD imaging classification task; then introduce the commonly used deep learning classification models for AD diagnosis; secondly, we compare the studies that target different biomarkers of the subjects and the use of unimodal or a combination of different modalities for the early classification of AD; and finally, The challenges of AD classification are summarized and future research directions are proposed.