Research Article
α-Glucosidase Inhibitory Activity of Ethanolic Extract Gambier (Uncaria gambier Roxb) From Southeast Aceh As Antidiabetes
@INPROCEEDINGS{10.4108/eai.20-1-2018.2282446, author={Vera Viena and Muhammad Nizar}, title={α-Glucosidase Inhibitory Activity of Ethanolic Extract Gambier (Uncaria gambier Roxb) From Southeast Aceh As Antidiabetes}, proceedings={Proceedings of the 1st Workshop on Multidisciplinary and Its Applications Part 1, WMA-01 2018, 19-20 January 2018, Aceh, Indonesia}, publisher={EAI}, proceedings_a={WMA-1}, year={2019}, month={9}, keywords={α-glukosidase inhibitory activity gambier antidiabetes}, doi={10.4108/eai.20-1-2018.2282446} }- Vera Viena
Muhammad Nizar
Year: 2019
α-Glucosidase Inhibitory Activity of Ethanolic Extract Gambier (Uncaria gambier Roxb) From Southeast Aceh As Antidiabetes
WMA-1
EAI
DOI: 10.4108/eai.20-1-2018.2282446
Abstract
Plants continue to play an important role in the treatment of diabetes. Gambier (Uncaria gambier Roxb) is one of the plants used for commercial product as a betel meal for the Acehnese. In this research we studied the inhibition activity of α-glucosidase enzyme toward gambier ethanolic extract as antidiabetes. The extraction of leaves, twigs and commercial gambier were performed by maceration method using ethanol solvent for 3 x 24 hour. Analysis of inhibition activity of α-glucosidase enzyme from each extract was done using microplate-96 well method, then the IC50 value was determined. The results showed that the inhibition activity of alpha glucosidase enzyme against gambier ethanolic extract was giving positive result, in delaying the glucose adsorption, while the highest activity was found in gambier leaves of 96,446%. The IC50 values of gambier leaves extract were compared to positive control of acarbose (Glucobay®) atwith ratio of 35,532 ppm which equal to 0,262 ppm. In conclusion, the gambier ethanolic extract has the best inhibitory activity against the alpha glucosidase enzyme to inhibite the blood sugar level, which can be used as one of traditional herbal medicine (THM) product.
