Research Article
The Gut-Brain Connection: Exploring the Influence of the Microbiome on Colon Cancer Development and Treatment
@INPROCEEDINGS{10.4108/eai.13-11-2024.2355674, author={Uday Raj Sharma and Sushavan Roy and Manjunatha PM and Gurubasavaraja Swamy PM and Suresh Janadri and Surendra Vada and Haribabu. T and Nageena Taj and Gayathri SV}, title={The Gut-Brain Connection: Exploring the Influence of the Microbiome on Colon Cancer Development and Treatment}, proceedings={Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India}, publisher={EAI}, proceedings_a={FPCS}, year={2025}, month={8}, keywords={gut-brain axis colon cancer probiotics prebiotics faecal microbiota transplantation microbiome-based biomarkers}, doi={10.4108/eai.13-11-2024.2355674} }- Uday Raj Sharma
Sushavan Roy
Manjunatha PM
Gurubasavaraja Swamy PM
Suresh Janadri
Surendra Vada
Haribabu. T
Nageena Taj
Gayathri SV
Year: 2025
The Gut-Brain Connection: Exploring the Influence of the Microbiome on Colon Cancer Development and Treatment
FPCS
EAI
DOI: 10.4108/eai.13-11-2024.2355674
Abstract
The gut-brain axis is an intricate bidirectional communication system between the gastrointestinal tract and the central nervous system that the gut microbiota can commonly influence. Recent studies have shown that the gut microbiome is crucial for colorectal cancer development and progression. The focus is on the close interaction between the gut microbiota and the development of colon cancer by explaining the microbial composition, metabolic byproducts and immune modulation. We also investigated how dysbiosis can promote carcinogenesis through inflammation, genotoxicity and immune evasion. In addition, we consider promising microbiota-targeted therapeutic approaches, such as the use of probiotics and faecal microbiota transplantation, together with the development of biotherapeutics and their ability to improve conventional colon cancer treatments. By elucidating the gut-brain-microbiome interplay, this manuscript aims to provide a comprehensive understanding of its impact on colon cancer, opening new avenues for innovative and effective treatment modalities.
