Research Article
S-Benzyl-L-cysteine Based Schiff bases Containing Peptide Groups: Design, Synthesis, Characterization, Cyclic Voltammetry, Antimicrobial and Molecular Docking Studies
@INPROCEEDINGS{10.4108/eai.13-11-2024.2355671, author={Marulasiddeshwara MB and Dakshayani SS and Somashekar MN and Satheesh CE and Raghavendra Kumar P}, title={S-Benzyl-L-cysteine Based Schiff bases Containing Peptide Groups: Design, Synthesis, Characterization, Cyclic Voltammetry, Antimicrobial and Molecular Docking Studies}, proceedings={Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India}, publisher={EAI}, proceedings_a={FPCS}, year={2025}, month={8}, keywords={schiff base synthesis spectroscopy antimicrobial molecular docking}, doi={10.4108/eai.13-11-2024.2355671} }- Marulasiddeshwara MB
Dakshayani SS
Somashekar MN
Satheesh CE
Raghavendra Kumar P
Year: 2025
S-Benzyl-L-cysteine Based Schiff bases Containing Peptide Groups: Design, Synthesis, Characterization, Cyclic Voltammetry, Antimicrobial and Molecular Docking Studies
FPCS
EAI
DOI: 10.4108/eai.13-11-2024.2355671
Abstract
New Schiff bases, 5a-5d have been synthesized by the condensation of L-2amino-3-(benzylthio)-N-(3,4-dimethoxyphenethyl)propanamide (4) with substituted aldehydes such as 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, Orthovanillin and 3,5-ditertbutylsalicylaldehyde. The compounds were characterized by elemental and spectroscopic analysis. The antibacterial and antifungal activities of 5a-5d against pathogenic microbial strains revealed that they showed a considerable growth of inhibition. The insilico studies of 5a-5d within the active site of DNA Gyrase (PDB: 3G75) showed a favorable binding energies (-5.78 to -6.64 kcal/mol). Similarly, molecular docking with N-Myristoyl transferase (PDB: 1IYL) exhibited binding energies between -10.72 and -11.85 kcal/mol. Notably, compounds participated in hydrogen bonding with the target.
