Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Analysis of Neuron-Specific Enolase of Cerebrospinal Fluid and Post Mortem Serum of Blunt Head Trauma in Cause and Time of Death Determination

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283662,
        author={Rika  Susanti and Taufik  Hidayat},
        title={Analysis of Neuron-Specific Enolase of Cerebrospinal Fluid and Post Mortem Serum of Blunt Head Trauma in Cause and Time of Death Determination},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={blunt head trauma nse cause of death time of death determination},
        doi={10.4108/eai.13-11-2018.2283662}
    }
    
  • Rika Susanti
    Taufik Hidayat
    Year: 2019
    Analysis of Neuron-Specific Enolase of Cerebrospinal Fluid and Post Mortem Serum of Blunt Head Trauma in Cause and Time of Death Determination
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283662
Rika Susanti1,*, Taufik Hidayat1
  • 1: Forensic and Medicolegal Department, Faculty of Medicine, Andalas University, Padang
*Contact email: rikasusanti@med.unand.ac.id

Abstract

Blunt head trauma is the highest cause of death in criminal crime. Various attempts have been conducted to find alternative substitutes for the autopsy to determine the cause of death. NSE levels have been used as biomarkers in blunt head trauma in a living patient. The purpose of this study was to analyze NSE levels of CSF and serum in cause and time of death determination. This study was an experimental study with a post-test only group design, with the treatment of death due to blunt head trauma compared to deaths from acute ketamine poisoning. The number of treatment groups was 8, with samples of each group were 6 adult Sprague Dawley Rattus novergicus. NSE levels were examined at 0 hours, 1 hour, 2 hours and 3 hours after death. Analysis of NSE levels of CSF and serum in determining the cause and time of death was undertaken with the General Linear Model Repeated Measure test. We found increases in NSE levels of CSF and serum in both groups of deaths due to blunt head trauma and acute ketamine poisoning, and there was a significant difference between the two groups with p = 0.005 of serum NSE levels. There was no significant difference in the time of death between NSE levels of CSF and serum. Overall, there are increases in NSE levels of CSF and serum in deaths due to blunt head trauma and acute ketamine poisoning