Research Article
Global Information Processing in Gene Networks: Fault Tolerance
@INPROCEEDINGS{10.4108/ICST.BIONETICS2007.2426, author={Frank Emmert-Streib and Matthias Dehmer}, title={Global Information Processing in Gene Networks: Fault Tolerance}, proceedings={1st International ICST Workshop on Computing and Communications from Biological Systems: Theory and Applications}, proceedings_a={CCBS}, year={2008}, month={8}, keywords={Information Theory gene networks information processing robustness scale-free networks}, doi={10.4108/ICST.BIONETICS2007.2426} }
- Frank Emmert-Streib
Matthias Dehmer
Year: 2008
Global Information Processing in Gene Networks: Fault Tolerance
CCBS
IEEE
DOI: 10.4108/ICST.BIONETICS2007.2426
Abstract
In this paper we study the fault tolerance of gene networks. We assume single gene knockouts and investigate the effect this kind of perturbation has on the communication between genes globally. For our study we use directed scale-free networks resembling gene networks, e.g., signaling or proteinprotein interaction networks, and define a Markov process based on the network topology to model communication. This allows us to evaluate the spread of information in the network and, hence, detect differences due to single gene knockouts in the gene-gene communication asymptotically.
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