Research Article
Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI
@INPROCEEDINGS{10.4108/icst.mobihealth.2014.257529, author={Konstantinos Bromis and Irene Karanasiou and George Matsopoulos and Errikos Ventouras and Nikolaos Uzunoglu and Eustratios Karavasilis and Vasileios Kouloulias and Matilda Papathanasiou and Andreas Foteineas}, title={Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI}, proceedings={4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"}, publisher={IEEE}, proceedings_a={MOBIHEALTH}, year={2014}, month={12}, keywords={fmri; pci; resting state fmri; task-related fmri; small cell lung cancer; default mode network}, doi={10.4108/icst.mobihealth.2014.257529} }- Konstantinos Bromis
Irene Karanasiou
George Matsopoulos
Errikos Ventouras
Nikolaos Uzunoglu
Eustratios Karavasilis
Vasileios Kouloulias
Matilda Papathanasiou
Andreas Foteineas
Year: 2014
Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI
MOBIHEALTH
IEEE
DOI: 10.4108/icst.mobihealth.2014.257529
Abstract
As the use of prophylactic cranial irradiation (PCI) increases life expectancy in certain types of cancer, there is evidence that this technique may contribute to neurocognitive deficits. The aim of this research is to investigate functional connectivity in patients before and after being administered brain radiotherapy as well as their neurocognitive functionality, depending on the course of disease and the phase of treatment and time of clinical examination. In the current study we attempt to identify potential alterations in brain function during resting state and task-related functional magnetic resonance imaging (fMRI) in small cell lung cancer patients (SCLC) patients before PCI compared to healthy subjects. The brain regions that were activated for both groups during a sequential tapping task are consistent with previous studies. However, the patient group showed a lower level of activation in the primary somatosensory cortex bilaterally. During rest, the Default Mode Network (DMN) was identified in both groups. The results presented are subject to further investigation with larger patient and control group.
