4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"

Research Article

Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI

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  • @INPROCEEDINGS{10.4108/icst.mobihealth.2014.257529,
        author={Konstantinos Bromis and Irene Karanasiou and George Matsopoulos and Errikos Ventouras and Nikolaos Uzunoglu and Eustratios Karavasilis and Vasileios Kouloulias and Matilda Papathanasiou and Andreas Foteineas},
        title={Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI},
        proceedings={4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"},
        publisher={IEEE},
        proceedings_a={MOBIHEALTH},
        year={2014},
        month={12},
        keywords={fmri; pci; resting state fmri; task-related fmri; small cell lung cancer; default mode network},
        doi={10.4108/icst.mobihealth.2014.257529}
    }
    
  • Konstantinos Bromis
    Irene Karanasiou
    George Matsopoulos
    Errikos Ventouras
    Nikolaos Uzunoglu
    Eustratios Karavasilis
    Vasileios Kouloulias
    Matilda Papathanasiou
    Andreas Foteineas
    Year: 2014
    Analysis of resting state and task-related fMRI data in small cell lung cancer patients before undertaking PCI
    MOBIHEALTH
    IEEE
    DOI: 10.4108/icst.mobihealth.2014.257529
Konstantinos Bromis1,*, Irene Karanasiou1, George Matsopoulos1, Errikos Ventouras2, Nikolaos Uzunoglu1, Eustratios Karavasilis3, Vasileios Kouloulias4, Matilda Papathanasiou4, Andreas Foteineas4
  • 1: School of Electrical and Computer Eng., National Technical University of Athens
  • 2: Department of Biomedical Technology Engineering, Technological Educational Institution of Athens
  • 3: Research Unit of Radiology and Medical Imaging, National Kapodistrian University of Athens
  • 4: 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Athens, Greece
*Contact email: kmpromhs@gmail.com

Abstract

As the use of prophylactic cranial irradiation (PCI) increases life expectancy in certain types of cancer, there is evidence that this technique may contribute to neurocognitive deficits. The aim of this research is to investigate functional connectivity in patients before and after being administered brain radiotherapy as well as their neurocognitive functionality, depending on the course of disease and the phase of treatment and time of clinical examination. In the current study we attempt to identify potential alterations in brain function during resting state and task-related functional magnetic resonance imaging (fMRI) in small cell lung cancer patients (SCLC) patients before PCI compared to healthy subjects. The brain regions that were activated for both groups during a sequential tapping task are consistent with previous studies. However, the patient group showed a lower level of activation in the primary somatosensory cortex bilaterally. During rest, the Default Mode Network (DMN) was identified in both groups. The results presented are subject to further investigation with larger patient and control group.