4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"

Research Article

Tract-Based Spatial Statistics Analysis of Diffusion-Tensor Imaging Data in Patients with Small Cell Lung Cancer.

Download263 downloads
  • @INPROCEEDINGS{10.4108/icst.mobihealth.2014.257513,
        author={Sofia Benezi and Eustratios Karavasilis and Irene Karanasiou and George Matsopoulos and Eric Ventouras and Nikolaos Uzunoglu and Vasilios Kouloulias and Matilda Papathanasiou and Adreas Foteineas and Theodore Soldatos and Christin Iosif and Efstathios Efstathopoulos and Nikolaos Kelekis and Dimitrios Kelekis},
        title={Tract-Based Spatial Statistics Analysis of Diffusion-Tensor Imaging Data in Patients with Small Cell Lung Cancer.},
        proceedings={4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"},
        publisher={IEEE},
        proceedings_a={MOBIHEALTH},
        year={2014},
        month={12},
        keywords={diffusion tensor imaging dti tract- based spatial statistics tbss small cell lung cancer sclc prophylactic cranial irradiation pci fractional anisotropy fa},
        doi={10.4108/icst.mobihealth.2014.257513}
    }
    
  • Sofia Benezi
    Eustratios Karavasilis
    Irene Karanasiou
    George Matsopoulos
    Eric Ventouras
    Nikolaos Uzunoglu
    Vasilios Kouloulias
    Matilda Papathanasiou
    Adreas Foteineas
    Theodore Soldatos
    Christin Iosif
    Efstathios Efstathopoulos
    Nikolaos Kelekis
    Dimitrios Kelekis
    Year: 2014
    Tract-Based Spatial Statistics Analysis of Diffusion-Tensor Imaging Data in Patients with Small Cell Lung Cancer.
    MOBIHEALTH
    IEEE
    DOI: 10.4108/icst.mobihealth.2014.257513
Sofia Benezi1,*, Eustratios Karavasilis2, Irene Karanasiou1, George Matsopoulos1, Eric Ventouras3, Nikolaos Uzunoglu1, Vasilios Kouloulias4, Matilda Papathanasiou4, Adreas Foteineas4, Theodore Soldatos2, Christin Iosif2, Efstathios Efstathopoulos4, Nikolaos Kelekis4, Dimitrios Kelekis2
  • 1: National Technical University of Athens School of Electrical & Computer Engineering Microwave & Fiber Optics Laboratory
  • 2: Research Centre of Radiology and Imaging, “Evgenidion” General Hospital
  • 3: Department of Medical Instrumentation Technology, Technological Educational Institution of Athens
  • 4: National and Kapodistrian University of Athens, Division of Radiology-Radiotherapy II
*Contact email: sophiampenezi@gmail.com

Abstract

Prophylactic cranial irradiation (PCI) is known to improve survival to a significant degree in Small Cell Lung Cancer (SCLC) patients. The aim of our study is to investigate changes in structural connectivity between healthy-volunteers and patients with SCLC, before and after PCI treatment. In this preliminary study we use diffusion tensor imaging (DTI) to identify changes in white matter structure in patient group pre radiotherapy to control group. The results have showed alterations in white matter structure. In the patient group lower fractional anisotropy (FA) and higher eigenvalues in white matter regions are observed compared to the control group. The results presented herein are subject to further investigation with larger patient and control groups.