A Deterministic Model of the Adult Subventricular Neurogenesis

There is a significant interest in studying adult subventricular neurogenesis to understand its biological function. Adult subventricular neurogenesis results in migration of neuronal precursors from subventricular zone to the olfactory bulb through the rostral migratory stream where they get converted to neurons. In this paper, we present a deterministic model of this phenomenon. It demonstrates the steady production of sufficient number of neurons. We prove that our model is biologically feasible and it overcomes the limitations of previously reported models. We believe that our model will help in devising experiments to further improve the understanding of adult subventricular neurogenesis. We have performed agent-based simulation of the model proposed in this paper. The results of this simulation and the program for agent-based simulation is made available on a publicly accessible website.