Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey

Research Article

Ameliorating effect of Alteplase in bleomycin-induced pulmonary fibrosis in adult rats

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  • @INPROCEEDINGS{10.4108/eai.7-9-2021.2315497,
        author={Mahdi M. Thuwaini},
        title={Ameliorating effect of Alteplase in bleomycin-induced pulmonary fibrosis in adult rats},
        proceedings={Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey},
        publisher={EAI},
        proceedings_a={IMDC-IST},
        year={2022},
        month={1},
        keywords={alteplase bleomycin pulmonary fibrosis rats gsh sod hyp},
        doi={10.4108/eai.7-9-2021.2315497}
    }
    
  • Mahdi M. Thuwaini
    Year: 2022
    Ameliorating effect of Alteplase in bleomycin-induced pulmonary fibrosis in adult rats
    IMDC-IST
    EAI
    DOI: 10.4108/eai.7-9-2021.2315497
Mahdi M. Thuwaini1,*
  • 1: Department of laboratory Investigation, College of Medical and Healthy Techniques/ Southern Technical University
*Contact email: mahdi.murshd@stu.edu.iq

Abstract

The current research was designed to investigate the ameliorating effect of alteplase in bleomycin-induced pulmonary fibrosis in adult rats. Alteplase 0.9mg/ kg i.p. as a single dose daily for 3weeks, significantly ameliorated the declined serum levels of SOD and GSHpx, and significantly, decrease the elevated level of hydroxyproline in (BLM) treated rats. Sections of lung of BLM treated rats showed extensive damage of the lung tissue with loss of the normal alveolar architecture and the majority of the alveolar walls were occupied by collagenous fibers with diffuse cellular infiltration, with bands of collagen fibers, and an increased macrophages and fibroblast cells. Regard the lung of rats treated by alteplase in combination with (BLM) revealed that fibrotic lesions appeared less, with mild inflammatory cells, minimum blood vessels congestion and most parenchyma tissue appeared similar to normal structure. Therefore, the findings may be offer one of therapeutic strategy to prevent the lung fibrosis associated with anticancer therapy.