Research Article
Influence of Genetic polymorphism of IL-2 and IL-6 on susceptibility to Helicobacter pylori infection and prognosis of Gastroduodenal Diseases
@INPROCEEDINGS{10.4108/eai.7-9-2021.2314840, author={Khairallah A.S Mohammed and Methaq M. Neamah AL-Hilfi and Naael H. Ali and Ali Dawood AL-Hilfi}, title={Influence of Genetic polymorphism of IL-2 and IL-6 on susceptibility to Helicobacter pylori infection and prognosis of Gastroduodenal Diseases}, proceedings={Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey}, publisher={EAI}, proceedings_a={IMDC-IST}, year={2022}, month={1}, keywords={helicobacter pylori interleukin 6 interleukin 2 polymorphism}, doi={10.4108/eai.7-9-2021.2314840} }- Khairallah A.S Mohammed
Methaq M. Neamah AL-Hilfi
Naael H. Ali
Ali Dawood AL-Hilfi
Year: 2022
Influence of Genetic polymorphism of IL-2 and IL-6 on susceptibility to Helicobacter pylori infection and prognosis of Gastroduodenal Diseases
IMDC-IST
EAI
DOI: 10.4108/eai.7-9-2021.2314840
Abstract
We aimed to study the association of IL-6 -174G/C, -572G/C, and IL-2 −330T/G and +114T/G polymorphisms with the pathogenesis of H. pylori infections. PCR, DNA sequencing, and ELISA technique were used to characterize the IL-2 and IL-6 polymorphisms and to measure their serum levels in 24 H. pylori-positive patients (5 chronic gastritis, 17 peptic ulcer, 2 gastric cancer) and 13 healthy people. IL-6 -174GG genotype was the most frequent (75%) among patients at higher risk of gastric cancer (OR: 4.8, P <0.05). A high prevalence of IL-6-572GG genotype (66.7%) was observed among patients with a possible risk of gastric cancer in subjects carrying GC genotype (OR: 2.7, P >0.05). IL-2 -330TT and +114TG genotypes were most frequent (58.3%, 50% respectively) among patients, with a possible risk of gastric cancer in patients carrying IL-2-330GG (OR: 2.4) and IL-2+114TT genotype (OR: 2.26). The serum levels of ILs -2/6 were varied about genetic variation.
