Research Article
Variation of Functional Monomers for The Preparation of Imprinted Polymers for Selective Analysis of Glibenclamide
@INPROCEEDINGS{10.4108/eai.6-11-2025.2364492, author={Lasmaryna Sirumapea and Ensiwi Munarsih and Mauizatul Hasanah and Hilma Hilma and Romsiah Romsiah and David Darwis}, title={Variation of Functional Monomers for The Preparation of Imprinted Polymers for Selective Analysis of Glibenclamide}, proceedings={Proceedings of the 4th Sriwijaya International Conference on Basic and Applied Sciences, SICBAS 2025, 6 November 2025, Palembang, Indonesia}, publisher={EAI}, proceedings_a={SICBAS}, year={2026}, month={8}, keywords={Functional monomer glibenclamide molecular imprinting technology}, doi={10.4108/eai.6-11-2025.2364492} }- Lasmaryna Sirumapea
Ensiwi Munarsih
Mauizatul Hasanah
Hilma Hilma
Romsiah Romsiah
David Darwis
Year: 2026
Variation of Functional Monomers for The Preparation of Imprinted Polymers for Selective Analysis of Glibenclamide
SICBAS
EAI
DOI: 10.4108/eai.6-11-2025.2364492
Abstract
The Molecular imprinting technology has been applied for glibenclamide, an antidiabetic drug. Synthesis was conducted on bulk polymerization method. The component of polymers is: trimethylolpropane trimethacrylate (TRIM) as crosslinker, chloroform and methanol as the porogen solvent, benzoyl peroxide as initiator and methacrylic acid (MA), ithaconic acid (ITA) were the various functional monomer. Soxlet extraction was conducted on the mixture of acetic acid: methanol (15:85). Physical characterization included functional group identification using Fourier Transform Infrared (FTIR) spectrophotometer, showed that the polymers met the qualification of imprinted polymer- new peaks found indicated that analyte has been successfully grafted to the polymers. Morphology elaboration using Scanning Elctron Microscope (SEM). Adsorption performace was represent by imprinting factor (IF) and α (analogue selectivity). Imprinting factor for MA and ITA found respectively: 1.22 and 1.30 The α points showed those three polymers are selective for glibenclamide better than those for analogue molecules.
