Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, Ruteng, Flores, Indonesia

Research Article

Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum Burmannii (Nees & T. Nees) Blume) From Kerinci Regency of Indonesia

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  • @INPROCEEDINGS{10.4108/eai.3-6-2021.2310732,
        author={Budiastuti  Budiastuti and Sukardiman  Sukardiman and Riesta  Primaharinastiti and Rosy Dwi Nurcholida},
        title={Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum Burmannii (Nees \& T. Nees) Blume) From Kerinci Regency of Indonesia },
        proceedings={Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, Ruteng, Flores, Indonesia},
        publisher={EAI},
        proceedings_a={ICEHHA},
        year={2021},
        month={8},
        keywords={cinnamomum burmannii; anti-inflamatory; tnf-α},
        doi={10.4108/eai.3-6-2021.2310732}
    }
    
  • Budiastuti Budiastuti
    Sukardiman Sukardiman
    Riesta Primaharinastiti
    Rosy Dwi Nurcholida
    Year: 2021
    Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum Burmannii (Nees & T. Nees) Blume) From Kerinci Regency of Indonesia
    ICEHHA
    EAI
    DOI: 10.4108/eai.3-6-2021.2310732
Budiastuti Budiastuti1,*, Sukardiman Sukardiman1, Riesta Primaharinastiti1, Rosy Dwi Nurcholida1
  • 1: Faculty of Pharmacy, Universitas Airlangga Surabaya, Indonesia
*Contact email: diashelmi@yahoo.com

Abstract

Introduction: Cinnamomum burmannii (Nees & T. Nees) Blume which has the main content of Cinnamaldehyde has an anti-inflammatory effect. Research on the anti-inflammatory effect of the essential oil of the bark of C. burmannii from Kerinci Regency (CBOK) has been conducted. Methods: The anti-inflammatory test of CBOK was carried out using Wistar rats. The anti-inflammatory test was carried out by using the paw test. The volume increase in paw due to swelling were measured. Histopathological analysis was performed by counting inflammatory cells and expression of TNF- α. The data analyzed were edema volume inhibition, the number of inflammatory cells and the expression of TNF-α. Results: There was a significant difference in the increase in inhibition of edema in the administration of CBOK compared to the negative control. A decrease in the number of inflammatory cells and TNF-α expression were observed. Thus, in this study of CBOK has anti-inflammatory effects.