Research Article
Characterization of E. coli Gene Regulatory Network and its Topological Enhancement by Edge Rewiring
@INPROCEEDINGS{10.4108/eai.3-12-2015.2262418, author={Satyaki Roy and Vijay Shah and Sajal Das}, title={Characterization of E. coli Gene Regulatory Network and its Topological Enhancement by Edge Rewiring}, proceedings={9th EAI International Conference on Bio-inspired Information and Communications Technologies (formerly BIONETICS)}, publisher={ACM}, proceedings_a={BICT}, year={2016}, month={5}, keywords={robustness three-tier topology edge rewiring motif-based centrality}, doi={10.4108/eai.3-12-2015.2262418} }- Satyaki Roy
Vijay Shah
Sajal Das
Year: 2016
Characterization of E. coli Gene Regulatory Network and its Topological Enhancement by Edge Rewiring
BICT
EAI
DOI: 10.4108/eai.3-12-2015.2262418
Abstract
The innate resilience of biological organisms have long inspired the design of robust systems. Gene regulatory network (GRN) is one such biological network which possesses a gamut of topological properties that contribute to its robustness. In this work, we study E. coli GRN as a three-tier topology to characterize such properties and explain why GRN is particularly vulnerable to failure of hub nodes. We also propose an edge rewiring mechanism on existing E. coli GRN topology to strengthen its robustness against hub failure. With extensive experiments on E. coli GRN, we show that its topological properties improve significantly after applying edge rewiring. Finally, we design wireless sensor networks using original and rewired E. coli GRN topologies. Simulation results indicate that rewired GRN has higher packet delivery and lower latency than original GRN.
