Effect of Olive Leaves Extract on Alloxan Induced Diabetes in Male Albino Mice

The current study was aimed to evaluate the effect of olive leaves extract (OLE) on alloxan-induced diabetic male mice. The experimental mice were divided into five groups. mice of the first group were considered as normal controls. mice of the 2nd group were diabetic control. The 3rd,4th, and 5th groups were diabetic mice, treated with a daily oral dose of OLE (100 mg/kg) for one, two, and three weeks respectively. According to the biochemical observations, the levels of serum glucose, urea, and creatine were significantly increased parallel with detectable histopathological sections in kidney tissues of mice. Furthermore, there was a significant decrease in serum glucose, urea, and creatine of diabetic group under treatment with OLE as a contrast to diabetic mice. Besides, histological findings appeared improved renal architecture as reflected by reduced glomerular and return of Bowman's capsule to nearly normal structure in mice when compared with the control group. Collectively, Oral administration of aqueous olive leaf extracts to diabetic mice proven that the protective effects of OLE are referred to the antioxidant activities and active constituents of olive leaves extract.