Research Article
Bienertia Sinuspersici Leaves Extracts Accelerated Wound Healing in laboratory animals
@INPROCEEDINGS{10.4108/eai.28-6-2020.2297924, author={Fatimah Jasim and Fatima Abass}, title={Bienertia Sinuspersici Leaves Extracts Accelerated Wound Healing in laboratory animals}, proceedings={Proceedings of the 1st International Multi-Disciplinary Conference Theme: Sustainable Development and Smart Planning, IMDC-SDSP 2020, Cyperspace, 28-30 June 2020}, publisher={EAI}, proceedings_a={IMDC-SDSP}, year={2020}, month={9}, keywords={accelerating wound healing; bienertia sinuspersici; cutaneous treatment; excision wound; incision wound}, doi={10.4108/eai.28-6-2020.2297924} }- Fatimah Jasim
Fatima Abass
Year: 2020
Bienertia Sinuspersici Leaves Extracts Accelerated Wound Healing in laboratory animals
IMDC-SDSP
EAI
DOI: 10.4108/eai.28-6-2020.2297924
Abstract
The skin physiological differences between humans and animals, therefore, it is difficult to study wound healing procedures in animals. Moreover, there are raising for using animals for testing the therapeutic possessions of new compounds. Hence, the present study was conducted to establish an excisional and incisional model of skin wound healing to estimated the wound healing capability of Bienertia sinuspersici leaves, through histopathological examination by using 18 male rats divided into two types of the wound (incision and excision); each type contained 3 groups ( 3 rats each): Control Group: treated by cream without 5% extract; Experimental Group: treated by 5% extract cream; Positive Control Group.: Treated with commercial cream. The result detected regeneration of the epidermis in the excision area was finished after 12 days post-surgery while in incision wounds, the epithelization interval for the positive control group, the negative control group, and the extract group were 10-12, 8-10, and 6-8 days, respectively. Increased in fibroblast as well as collagen fiber in an excision area for all groups with necrotic representation by deep eosinophilic staining area in some regions of control and positive groups was observed. Histopathological examination of the drug-treated groups' section revealed reducing the hair follicle and sweat glands in an excision area as well as in control groups but the B. sinuspersici showed some of the hair follicles appeared in this area.
