Proceedings of the 1st International Conference on Health Science, ICHS 2020, 26-27 October 2020, Jakarta, Indonesia

Research Article

Preformulation Study of 50% Ethanol Extract of Mangosteen Rind (Garcinia mangostana L.)

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  • @INPROCEEDINGS{10.4108/eai.26-10-2020.2311315,
        author={Sabrina  Dahlizar and Yuni  Anggraeni and Hanny  Narulita},
        title={Preformulation Study of 50\% Ethanol Extract of Mangosteen Rind (Garcinia mangostana L.)},
        proceedings={Proceedings of the 1st International Conference on Health Science, ICHS 2020, 26-27 October 2020, Jakarta, Indonesia},
        publisher={EAI},
        proceedings_a={ICHS},
        year={2021},
        month={8},
        keywords={alpha mangostin garcinia mangostana l specific parameter solubility stability},
        doi={10.4108/eai.26-10-2020.2311315}
    }
    
  • Sabrina Dahlizar
    Yuni Anggraeni
    Hanny Narulita
    Year: 2021
    Preformulation Study of 50% Ethanol Extract of Mangosteen Rind (Garcinia mangostana L.)
    ICHS
    EAI
    DOI: 10.4108/eai.26-10-2020.2311315
Sabrina Dahlizar1,*, Yuni Anggraeni1, Hanny Narulita1
  • 1: Pharmacy Study Program, Faculty of Health Sciences UIN Syarif Hidayatullah Jakarta, Ciputat, 15419. Indonesia
*Contact email: sabrina@uinjkt.ac.id

Abstract

Garcinia mangostana rind containing alpha-mangostin has the potential to be used as an antioxidant. This study aimed to determine the physicochemical properties and stability of alpha-mangosteen in the 50% ethanol extract of mangosteen rind as a parameter in the pre-formulation study. Physicochemical properties were evaluated for specific and nonspecific extract parameters, determining the optimum wavelength and solubility test. The stability test was carried out at a temperature of 45±5°C with relative humidity 75±5% for 21 days, in acidic and alkaline conditions. The alpha-mangostin content was analyzed using a UV-Vis spectrophotometer. The results showed that the extract was purplish brown, has an aromatic smell, and a bitter taste. The dissolved compound in water and ethanol were 62.54±1.09% and 87.05±0,43%, respectively, the specific density of 5% extract was 1.036, loss on drying 6.66±0,11%, ash content 5.07±0.23%, ash content insoluble in acidic was 0.13±0.02%, alpha-mangosteen content in the extract was 3.85±0.03%. The solubility test showed that alpha-mangosteen in the extract has a solubility value of 1: 16064 in water. The stability test showed that the levels of alpha-mangostin decreased significantly (p≤ 0.05) at 45±5°C and relative humidity 75±5% for 21 days. Mangosteen rind extract was unstable in the extremely acidic and alkaline conditions.