bebi 22(4): e4

Research Article

Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor

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  • @ARTICLE{10.4108/eai.25-3-2022.173714,
        author={Danijela Cvetković and Aleksandar Cvetković and Danijela Nikodijević and Jovana Jovankić and Milena Milutinović and Vladislava Stojić and Nataša Zdravković and Slobodanka Mitrović},
        title={Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor},
        journal={EAI Endorsed Transactions on Bioengineering and Bioinformatics},
        volume={1},
        number={4},
        publisher={EAI},
        journal_a={BEBI},
        year={2022},
        month={3},
        keywords={Breast cancer, Peritumoral tissue, VEGF, CXCR-4, Predictive factor},
        doi={10.4108/eai.25-3-2022.173714}
    }
    
  • Danijela Cvetković
    Aleksandar Cvetković
    Danijela Nikodijević
    Jovana Jovankić
    Milena Milutinović
    Vladislava Stojić
    Nataša Zdravković
    Slobodanka Mitrović
    Year: 2022
    Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor
    BEBI
    EAI
    DOI: 10.4108/eai.25-3-2022.173714
Danijela Cvetković1,*, Aleksandar Cvetković2, Danijela Nikodijević3, Jovana Jovankić3, Milena Milutinović3, Vladislava Stojić4, Nataša Zdravković5, Slobodanka Mitrović6
  • 1: University of Kragujevac, Institute for Information Technologies, Department of Science, Kragujevac, Serbia
  • 2: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Surgery, Kragujevac, Serbia
  • 3: University of Kragujevac, Faculty of Sciences, Department of Biology and Ecology, Kragujevac, Serbia
  • 4: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Medical Statistics and Informatics, Kragujevac, Serbia
  • 5: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Internal medicine, Kragujevac, Serbia
  • 6: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia
*Contact email: danijela.cvetkovic@uni.kg.ac.rs

Abstract

INTRODUCTION: Despite the obvious progress in the field of diagnosis and therapy, further measures are needed to increase the effectiveness of treatment and reduce morbidity and mortality from breast cancer.

OBJECTIVES: To study the influence of peritumoral tissue on the growth and development of the tumor itself.

METHODS: An immunofluorescence method was used to determine the protein expression of VEGF and CXCR-4 in tumor and peritumoral tissue.

RESULTS: Peritumoral tissue is not only a passive factor, but actively participates in the process of tumor growth and development, as well as in the processes of recurrence and metastasis.

CONCLUSION: Markers of neoangiogenesis in tumor and peritumoral tissue such as protein expression of VEGF and CXCR-4 receptors may serve as reliable predictors of disease outcome in breast cancer patients, which may provide useful suggestions in treatment choices.