Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor

Danijela Cvetković; Aleksandar Cvetković; Danijela Nikodijević; Jovana Jovankić; Milena Milutinović; Vladislava Stojić; Nataša Zdravković; Slobodanka Mitrović

Research Article

Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor

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@ARTICLE{10.4108/eai.25-3-2022.173714,
    author={Danijela Cvetković and Aleksandar Cvetković and Danijela Nikodijević and Jovana Jovankić and Milena Milutinović and Vladislava Stojić and Nataša Zdravković and Slobodanka Mitrović},
    title={Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor},
    journal={EAI Endorsed Transactions on Bioengineering and Bioinformatics},
    volume={1},
    number={4},
    publisher={EAI},
    journal_a={BEBI},
    year={2022},
    month={3},
    keywords={Breast cancer, Peritumoral tissue, VEGF, CXCR-4, Predictive factor},
    doi={10.4108/eai.25-3-2022.173714}
}

Danijela Cvetković
Aleksandar Cvetković
Danijela Nikodijević
Jovana Jovankić
Milena Milutinović
Vladislava Stojić
Nataša Zdravković
Slobodanka Mitrović
Year: 2022
Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor
BEBI
EAI
DOI: 10.4108/eai.25-3-2022.173714

Danijela Cvetković¹^,*, Aleksandar Cvetković², Danijela Nikodijević³, Jovana Jovankić³, Milena Milutinović³, Vladislava Stojić⁴, Nataša Zdravković⁵, Slobodanka Mitrović⁶

1: University of Kragujevac, Institute for Information Technologies, Department of Science, Kragujevac, Serbia
2: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Surgery, Kragujevac, Serbia
3: University of Kragujevac, Faculty of Sciences, Department of Biology and Ecology, Kragujevac, Serbia
4: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Medical Statistics and Informatics, Kragujevac, Serbia
5: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Internal medicine, Kragujevac, Serbia
6: University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia

*Contact email: danijela.cvetkovic@uni.kg.ac.rs

Abstract

INTRODUCTION: Despite the obvious progress in the field of diagnosis and therapy, further measures are needed to increase the effectiveness of treatment and reduce morbidity and mortality from breast cancer.

OBJECTIVES: To study the influence of peritumoral tissue on the growth and development of the tumor itself.

METHODS: An immunofluorescence method was used to determine the protein expression of VEGF and CXCR-4 in tumor and peritumoral tissue.

RESULTS: Peritumoral tissue is not only a passive factor, but actively participates in the process of tumor growth and development, as well as in the processes of recurrence and metastasis.

CONCLUSION: Markers of neoangiogenesis in tumor and peritumoral tissue such as protein expression of VEGF and CXCR-4 receptors may serve as reliable predictors of disease outcome in breast cancer patients, which may provide useful suggestions in treatment choices.

Keywords: Breast cancer, Peritumoral tissue, VEGF, CXCR-4, Predictive factor

Received: 2021-11-19
Accepted: 2022-03-23
Published: 2022-03-25
Publisher: EAI

: http://dx.doi.org/10.4108/eai.25-3-2022.173714

Copyright © 2022 Danijela Cvetković et al., licensed to EAI. This is an open access article distributed under the terms of the Creative Commons Attribution license, which permits unlimited use, distribution and reproduction in any medium so long as the original work is properly cited.