Histopathology of Liver and Cardiac Muscle of  Alloxan-Induced Diabetic Rats (Rattus norvegicus)  After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

Adriana Y.D. Lbn Gaol; Marojahan Sijabat; Jhon Saragih; Eko Prasetya; Ayup Ningsih; Herbert Sipahutar

Proceedings of the 5th International Conference on Innovation in Education, Science, and Culture, ICIESC 2023, 24 October 2023, Medan, Indonesia

Research Article

Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

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@INPROCEEDINGS{10.4108/eai.24-10-2023.2342144,
    author={Adriana Y.D. Lbn Gaol and Marojahan Hasudungan Sijabat and Jhon Alpin Daniel Saragih and Eko Prasetya and Ayup Putri Ningsih and Herbert Sipahutar},
    title={Histopathology of Liver and Cardiac Muscle of  Alloxan-Induced Diabetic Rats (Rattus norvegicus)  After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract},
    proceedings={Proceedings of the 5th International Conference on Innovation in Education, Science, and Culture, ICIESC 2023, 24 October 2023, Medan, Indonesia},
    publisher={EAI},
    proceedings_a={ICIESC},
    year={2024},
    month={1},
    keywords={bosibosi (timonius flavescens) rats diabetes liver and heart histopathology},
    doi={10.4108/eai.24-10-2023.2342144}
}

Adriana Y.D. Lbn Gaol
Marojahan Hasudungan Sijabat
Jhon Alpin Daniel Saragih
Eko Prasetya
Ayup Putri Ningsih
Herbert Sipahutar
Year: 2024
Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract
ICIESC
EAI
DOI: 10.4108/eai.24-10-2023.2342144

Adriana Y.D. Lbn Gaol¹, Marojahan Hasudungan Sijabat¹, Jhon Alpin Daniel Saragih¹, Eko Prasetya¹, Ayup Putri Ningsih¹, Herbert Sipahutar¹^,*

1: Department of Biology, Faculty of Matemathics and Natural Sciences, Universitas Negeri Medan

*Contact email: herbertsipahutar@unimed.ac.id

Abstract

This research was aimed to study the effect of ethanol extract of bosibosi leaves (Timonius flavescens) (EEBL) on histopathology of liver and cardiac muscles of diabetic male rats. Animals (25) were randomly distributed into groups of NC (normal + NaCl), DC (diabetes + NaCl), DM (diabetes + metformin), DE300 (diabetes + EEBL 300) and DE500 (diabetes + EEBL 500 mg/kg bw/day); treated for 28 consecutive days and sacrificed for tissue collection. Tissues were processed (formalin, paraffin, H & E) and examined for histopathology. All diabetic rats showed hepatic tissue necrosis which is characterized by pycnotic nuclei, karyorhexis and karyolysis. The order of groups based on the percentage tissue damage is NC (27.61±2.44), DM (38.62±3.87), DE500 (45.15±3.76), DE300 (61.20±5.51) and DC (75.17±3.21). Cardiac muscle shows cell damage form mild degeneration to necrosis. The results indicate the potential of EEBL to repair tissues damaged by diabetes

Keywords: bosibosi (timonius flavescens) rats diabetes liver and heart histopathology

Published: 2024-01-25
Publisher: EAI

: http://dx.doi.org/10.4108/eai.24-10-2023.2342144

Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

Abstract

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