Proceedings of the 5th International Conference on Innovation in Education, Science, and Culture, ICIESC 2023, 24 October 2023, Medan, Indonesia

Research Article

Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract

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  • @INPROCEEDINGS{10.4108/eai.24-10-2023.2342144,
    author={Adriana Y.D. Lbn Gaol and Marojahan Hasudungan Sijabat and Jhon Alpin Daniel Saragih and Eko Prasetya and Ayup Putri Ningsih and Herbert Sipahutar},
    title={Histopathology of Liver and Cardiac Muscle of  Alloxan-Induced Diabetic Rats (Rattus norvegicus)  After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract},
    proceedings={Proceedings of the 5th International Conference on Innovation in Education, Science, and Culture, ICIESC 2023, 24 October 2023, Medan, Indonesia},
    publisher={EAI},
    proceedings_a={ICIESC},
    year={2024},
    month={1},
    keywords={bosibosi (timonius flavescens) rats diabetes liver and heart histopathology},
    doi={10.4108/eai.24-10-2023.2342144}
}
  • Adriana Y.D. Lbn Gaol
    Marojahan Hasudungan Sijabat
    Jhon Alpin Daniel Saragih
    Eko Prasetya
    Ayup Putri Ningsih
    Herbert Sipahutar
    Year: 2024
    Histopathology of Liver and Cardiac Muscle of Alloxan-Induced Diabetic Rats (Rattus norvegicus) After Administration of Bosibosi (Timonius flavescens (Jacq.) Baker) Leaves Ethanol Extract
    ICIESC
    EAI
    DOI: 10.4108/eai.24-10-2023.2342144
Adriana Y.D. Lbn Gaol1, Marojahan Hasudungan Sijabat1, Jhon Alpin Daniel Saragih1, Eko Prasetya1, Ayup Putri Ningsih1, Herbert Sipahutar1,*
  • 1: Department of Biology, Faculty of Matemathics and Natural Sciences, Universitas Negeri Medan
*Contact email: herbertsipahutar@unimed.ac.id

Abstract

This research was aimed to study the effect of ethanol extract of bosibosi leaves (Timonius flavescens) (EEBL) on histopathology of liver and cardiac muscles of diabetic male rats. Animals (25) were randomly distributed into groups of NC (normal + NaCl), DC (diabetes + NaCl), DM (diabetes + metformin), DE300 (diabetes + EEBL 300) and DE500 (diabetes + EEBL 500 mg/kg bw/day); treated for 28 consecutive days and sacrificed for tissue collection. Tissues were processed (formalin, paraffin, H & E) and examined for histopathology. All diabetic rats showed hepatic tissue necrosis which is characterized by pycnotic nuclei, karyorhexis and karyolysis. The order of groups based on the percentage tissue damage is NC (27.61±2.44), DM (38.62±3.87), DE500 (45.15±3.76), DE300 (61.20±5.51) and DC (75.17±3.21). Cardiac muscle shows cell damage form mild degeneration to necrosis. The results indicate the potential of EEBL to repair tissues damaged by diabetes

Keywords
bosibosi (timonius flavescens) rats diabetes liver and heart histopathology
Published
2024-01-25
Publisher
EAI
http://dx.doi.org/10.4108/eai.24-10-2023.2342144
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