1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia

Research Article

Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate

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  • @INPROCEEDINGS{10.4108/eai.2-5-2019.2284630,
        author={Riswandi  Riswandi and Prihantono  Prihantono and Indah  Raya and Rizal  Irfandi},
        title={Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate },
        proceedings={1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia},
        publisher={EAI},
        proceedings_a={ICOST},
        year={2019},
        month={6},
        keywords={complexes isoleucine dithiocarbamate mcf-7},
        doi={10.4108/eai.2-5-2019.2284630}
    }
    
  • Riswandi Riswandi
    Prihantono Prihantono
    Indah Raya
    Rizal Irfandi
    Year: 2019
    Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate
    ICOST
    EAI
    DOI: 10.4108/eai.2-5-2019.2284630
Riswandi Riswandi1,*, Prihantono Prihantono2, Indah Raya1, Rizal Irfandi1
  • 1: Department of Chemistry, Faculty of Mathematics, and Natural Science, Universitas Hasanuddin, Indonesia. 90245
  • 2: Department of Surgery, Faculty of Medical, Universitas Hasanuddin, Indonesia. 90245
*Contact email: wandykimia@gmail.com

Abstract

The "in situ" method is used to synthesize the Mg (II) isoleucinedithiocarbamate complex. This complex is characterized by using Ultraviolet-Visible Spectroscopy (UV-Vis) and Infra Red (IR) Spectrum maximum. In addition, measurements of melting and conductivity are also carried out. The results obtained for UV-Vis Mg (II) isoleucinedithiocarbamate at 267 nm and 486 nm indicate that electronic transitions π → π * and n→π* from CS2 and N = C = S. IR spectra at wavelengths in region 391- 536 cm-1 shows that there has been coordination between Mg (II) and Sulfur (S) atoms, Nitrogen (N) and Oxygen (O) from the isoleucinedithiocarbamate ligand. Cytotoxic test of the Mg (II) isoleucinedithiocarbamate complex has IC50 = 11008.33 μg / mL. These results indicate that MCF-7 cells undergo apoptosis seen from morphological changes.