Research Article
Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate
@INPROCEEDINGS{10.4108/eai.2-5-2019.2284630, author={Riswandi Riswandi and Prihantono Prihantono and Indah Raya and Rizal Irfandi}, title={Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate }, proceedings={1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia}, publisher={EAI}, proceedings_a={ICOST}, year={2019}, month={6}, keywords={complexes isoleucine dithiocarbamate mcf-7}, doi={10.4108/eai.2-5-2019.2284630} }- Riswandi Riswandi
Prihantono Prihantono
Indah Raya
Rizal Irfandi
Year: 2019
Potential of Breast Anticancer Compounds (MCF-7) from Synthesis Results and Characterization of Complex Compounds of Mg(II) Isoleucinedithiocarbamate
ICOST
EAI
DOI: 10.4108/eai.2-5-2019.2284630
Abstract
The "in situ" method is used to synthesize the Mg (II) isoleucinedithiocarbamate complex. This complex is characterized by using Ultraviolet-Visible Spectroscopy (UV-Vis) and Infra Red (IR) Spectrum maximum. In addition, measurements of melting and conductivity are also carried out. The results obtained for UV-Vis Mg (II) isoleucinedithiocarbamate at 267 nm and 486 nm indicate that electronic transitions π → π * and n→π* from CS2 and N = C = S. IR spectra at wavelengths in region 391- 536 cm-1 shows that there has been coordination between Mg (II) and Sulfur (S) atoms, Nitrogen (N) and Oxygen (O) from the isoleucinedithiocarbamate ligand. Cytotoxic test of the Mg (II) isoleucinedithiocarbamate complex has IC50 = 11008.33 μg / mL. These results indicate that MCF-7 cells undergo apoptosis seen from morphological changes.
