1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia

Research Article

Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex

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  • @INPROCEEDINGS{10.4108/eai.2-5-2019.2284628,
        author={Rizal  Irfandi and Prihantono  Prihantono and Indah  Raya and Desy  Kartina and Riswandi  Riswandi},
        title={Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex },
        proceedings={1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia},
        publisher={EAI},
        proceedings_a={ICOST},
        year={2019},
        month={6},
        keywords={complexes cysteine dithiocarbamate apoptosis mcf-7},
        doi={10.4108/eai.2-5-2019.2284628}
    }
    
  • Rizal Irfandi
    Prihantono Prihantono
    Indah Raya
    Desy Kartina
    Riswandi Riswandi
    Year: 2019
    Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex
    ICOST
    EAI
    DOI: 10.4108/eai.2-5-2019.2284628
Rizal Irfandi1,*, Prihantono Prihantono2, Indah Raya1, Desy Kartina1, Riswandi Riswandi1
  • 1: Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Hasanuddin, Makassar, Indonesia. 90245
  • 2: Department of Surgery, Faculty of Medical, Universitas Hasanuddin, Makassar, Indonesia. 90245
*Contact email: rizalirfandi043@gmail.com

Abstract

Fe(II)cysteindithiocarbamate complex has been synthesized by an in-situ method. Complex characterized using Ultra Violet Visible (UV-Vis), Infra Red (IR), melting point and molar conductivity. The presence of UV-Vis maximum spectrums of Fe(II)cysteindithiocarbamate at 245 nm and 354 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S. While the presence of IR spectra at the wavelength in the region of 393-540 cm-1 indicated that has been coordination occurred between Fe(II) with Sulphur (S), Nitrogen (N) and Oxygen(O) atoms from cysteinedithiocarbamate ligands. Anticancer activity tests of Fe(II) complex and metals without ligands on the breast cancer cell line (MCF-7) were carried out in vitro. The results of the cytotoxicity test showed that Fe(II) complex had the potential as an anticancer for MCF-7 cancer cells compared to metals without ligands which showed a non-toxic effect on cancer cells.