Research Article
Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex
@INPROCEEDINGS{10.4108/eai.2-5-2019.2284628, author={Rizal Irfandi and Prihantono Prihantono and Indah Raya and Desy Kartina and Riswandi Riswandi}, title={Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex }, proceedings={1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia}, publisher={EAI}, proceedings_a={ICOST}, year={2019}, month={6}, keywords={complexes cysteine dithiocarbamate apoptosis mcf-7}, doi={10.4108/eai.2-5-2019.2284628} }- Rizal Irfandi
Prihantono Prihantono
Indah Raya
Desy Kartina
Riswandi Riswandi
Year: 2019
Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex
ICOST
EAI
DOI: 10.4108/eai.2-5-2019.2284628
Abstract
Fe(II)cysteindithiocarbamate complex has been synthesized by an in-situ method. Complex characterized using Ultra Violet Visible (UV-Vis), Infra Red (IR), melting point and molar conductivity. The presence of UV-Vis maximum spectrums of Fe(II)cysteindithiocarbamate at 245 nm and 354 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S. While the presence of IR spectra at the wavelength in the region of 393-540 cm-1 indicated that has been coordination occurred between Fe(II) with Sulphur (S), Nitrogen (N) and Oxygen(O) atoms from cysteinedithiocarbamate ligands. Anticancer activity tests of Fe(II) complex and metals without ligands on the breast cancer cell line (MCF-7) were carried out in vitro. The results of the cytotoxicity test showed that Fe(II) complex had the potential as an anticancer for MCF-7 cancer cells compared to metals without ligands which showed a non-toxic effect on cancer cells.
