Research Article
Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology
@INPROCEEDINGS{10.4108/eai.2-10-2018.2295461, author={Himmatul Barroroh and Ayu Fitriana Dewi and Hafidatul Hasanah and Akyunul Akyunul}, title={Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology}, proceedings={Proceedings of the 2nd International Conference on Quran and Hadith Studies Information Technology and Media in Conjunction with the 1st International Conference on Islam, Science and Technology, ICONQUHAS \& ICONIST, Bandung, October 2-4, 2018, Indonesia}, publisher={EAI}, proceedings_a={ICONQUHAS}, year={2020}, month={5}, keywords={diabetes mellitus; extract; bitter melon; momordica; hematoxylin; eosin; he; therapy; blood glucose levels; natural product; alloxan; kidney}, doi={10.4108/eai.2-10-2018.2295461} }- Himmatul Barroroh
Ayu Fitriana Dewi
Hafidatul Hasanah
Akyunul Akyunul
Year: 2020
Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology
ICONQUHAS
EAI
DOI: 10.4108/eai.2-10-2018.2295461
Abstract
The aim of this research is to know the effect of short-term bitter melon (Momordica Charantia L.) fruit concentrated infusions therapy on the histology of alloxan-induced rat kidney glomerulus. Renal glomerular histology was observed using Hematoxylin-Eosin (HE) test. A therapeutic dose of bitter melon fruit concentrated therapy used was 0.15 mL/200 g BW; 0.30 mL/200 g BW; 0.45 mL/200 g BW; 0.60 mL/200 g BW; 0.80 mL/200 g BW and 1 mL/200 g BW. The results showed that the bitter melon fruit concentrated infusions therapy on alloxan-induced DM rats was able to decrease the Blood Glucose Levels (BGL) of the treated rats in varying degrees. The therapy also successfully repairs the damage kidney glomerulus cells of all rats treated with an average bowman's space improvement of 110% of healthy rat's kidney glomerulus cells. It appears that the mechanism of the bitter melon active substance in reducing the BGL occurs through a different path to its mechanism in repairing damaged glomerulus cells.
