Proceedings of the 2nd International Conference on Quran and Hadith Studies Information Technology and Media in Conjunction with the 1st International Conference on Islam, Science and Technology, ICONQUHAS & ICONIST, Bandung, October 2-4, 2018, Indonesia

Research Article

Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology

Download96 downloads
  • @INPROCEEDINGS{10.4108/eai.2-10-2018.2295461,
        author={Himmatul  Barroroh and Ayu Fitriana Dewi and Hafidatul  Hasanah and Akyunul  Akyunul},
        title={Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology},
        proceedings={Proceedings of the 2nd International Conference on Quran and Hadith Studies Information Technology and Media in Conjunction with the 1st International Conference on Islam, Science and Technology,  ICONQUHAS \& ICONIST, Bandung, October 2-4, 2018, Indonesia},
        publisher={EAI},
        proceedings_a={ICONQUHAS},
        year={2020},
        month={5},
        keywords={diabetes mellitus; extract; bitter melon; momordica; hematoxylin; eosin; he; therapy; blood glucose levels; natural product; alloxan; kidney},
        doi={10.4108/eai.2-10-2018.2295461}
    }
    
  • Himmatul Barroroh
    Ayu Fitriana Dewi
    Hafidatul Hasanah
    Akyunul Akyunul
    Year: 2020
    Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology
    ICONQUHAS
    EAI
    DOI: 10.4108/eai.2-10-2018.2295461
Himmatul Barroroh1,*, Ayu Fitriana Dewi1, Hafidatul Hasanah2, Akyunul Akyunul1
  • 1: Chemistry Department, Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim Jalan Gajayana 50 Malang, East Jawa, Indonesia
  • 2: Medical Service and Medical Supporting Unit RSUD Grati Pasuruan Jalan Raya Ranu Klindungan Grati, Pasuruan, East Java, Indonesia
*Contact email: himmatul.b@kim.uin-malang.ac.id

Abstract

The aim of this research is to know the effect of short-term bitter melon (Momordica Charantia L.) fruit concentrated infusions therapy on the histology of alloxan-induced rat kidney glomerulus. Renal glomerular histology was observed using Hematoxylin-Eosin (HE) test. A therapeutic dose of bitter melon fruit concentrated therapy used was 0.15 mL/200 g BW; 0.30 mL/200 g BW; 0.45 mL/200 g BW; 0.60 mL/200 g BW; 0.80 mL/200 g BW and 1 mL/200 g BW. The results showed that the bitter melon fruit concentrated infusions therapy on alloxan-induced DM rats was able to decrease the Blood Glucose Levels (BGL) of the treated rats in varying degrees. The therapy also successfully repairs the damage kidney glomerulus cells of all rats treated with an average bowman's space improvement of 110% of healthy rat's kidney glomerulus cells. It appears that the mechanism of the bitter melon active substance in reducing the BGL occurs through a different path to its mechanism in repairing damaged glomerulus cells.