Proceedings of the 2nd International Conference on Quran and Hadith Studies Information Technology and Media in Conjunction with the 1st International Conference on Islam, Science and Technology, ICONQUHAS & ICONIST, Bandung, October 2-4, 2018, Indonesia

Research Article

Inhibition Activity of Lung Cancer Cells A549 by Trigona Propolis From Indonesia

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  • @INPROCEEDINGS{10.4108/eai.2-10-2018.2295451,
        author={Achmad Tjachja Nugraha and La Ode Sumarlin},
        title={Inhibition Activity of Lung Cancer Cells A549 by Trigona Propolis From Indonesia},
        proceedings={Proceedings of the 2nd International Conference on Quran and Hadith Studies Information Technology and Media in Conjunction with the 1st International Conference on Islam, Science and Technology,  ICONQUHAS \& ICONIST, Bandung, October 2-4, 2018, Indonesia},
        publisher={EAI},
        proceedings_a={ICONQUHAS},
        year={2020},
        month={5},
        keywords={component; cell a549 lung cancer trigona propolis},
        doi={10.4108/eai.2-10-2018.2295451}
    }
    
  • Achmad Tjachja Nugraha
    La Ode Sumarlin
    Year: 2020
    Inhibition Activity of Lung Cancer Cells A549 by Trigona Propolis From Indonesia
    ICONQUHAS
    EAI
    DOI: 10.4108/eai.2-10-2018.2295451
Achmad Tjachja Nugraha1,*, La Ode Sumarlin2
  • 1: UIN Syarif Hidayatullah, Faculty of Science and Technology, Jakarta
  • 2: UIN Syarif Hidayatullah, Chemistry Faculty of Science and Technology Faculty, Jakarta
*Contact email: sumarlin@uinjkt.ac.id

Abstract

The results showed that propolis trigona has high content of flavonoids, vitamin C and β-carotene compounds. Therefore, the whole exploration effort of propolis properties becomes an important study and research especially anticancer activity of lung cancer. Trigona propolis samples which is used are from Indonesian beekeepers. Lung anticancer activity was measured by MTT method (3- (4,5-Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide) on A549 cell. The results showed the inhibition of A549 lung cancer cell by trigona propolis is higher with increasing concentration (0.625 to 100 ppm). The results of phytochemical analysis showed that the trigona propolis samples contained alkaloids, flavonoids, quinones and tannins. In addition, trigona propolis has the ability to inhibit A549 cells of 78.21 ± 0.02% at 100 ppm concentration. This inhibitory ability is higher in line with the increase in sample concentration. Therefore, Indonesian trigona propolis has potential as a lung anticancer.