Research Article
The Muntingia calabura Leaves Extract Effect on Respiration and Heart Performance of Zebrafish (Danio rerio): The Search for Covid-19 Control Agent
@INPROCEEDINGS{10.4108/eai.19-12-2020.2309153, author={Siti Zar’ah and Bambang Retnoaji}, title={The Muntingia calabura Leaves Extract Effect on Respiration and Heart Performance of Zebrafish (Danio rerio): The Search for Covid-19 Control Agent}, proceedings={Proceedings of The 6th Asia-Pacific Education And Science Conference, AECon 2020, 19-20 December 2020, Purwokerto, Indonesia}, publisher={EAI}, proceedings_a={AECON}, year={2021}, month={8}, keywords={mutingia calabura leaves zebrafish heart rate respiration}, doi={10.4108/eai.19-12-2020.2309153} }- Siti Zar’ah
Bambang Retnoaji
Year: 2021
The Muntingia calabura Leaves Extract Effect on Respiration and Heart Performance of Zebrafish (Danio rerio): The Search for Covid-19 Control Agent
AECON
EAI
DOI: 10.4108/eai.19-12-2020.2309153
Abstract
Currently, the world community faces the Covid-19 pandemic phenomenon since December 2019 and has caused many victims. Various methods have been used to prevent and treat patients affected by this viral infection, especially in medical care. In addition to medical efforts, exploring natural material potential as a controlling agent for Covid-19 has been widely carried out. The purpose of this study was to examine the potential of Muntingia calabura as a controlling agent for Covid-19, by studying the secondary metabolite effects of Muntingia calabura leaves on zebrafish (Danio rerio). Research focuses on the administration of Muntingia calabura leaves extract and its impact on the organ respiration, heart rate and swim mobility on zebrafish (Danio rerio) by microscopic and macroscopic observations. The Muntingia calabura leaves were extracted following the soxhlet method, which then used as supplement of zebrafish feed. The zebrafish were divided into 5 groups, of control and those treated with leave extract of 0.5 mg/L, 0.25 mg/L, 0.1 mg/L, and BSA alone, respectively. The results showed that Muntingia calabura leaves extract caused significant effects on zebrafish that decreased operculum opening, heart rate, and swim mobility. Data were analyzed with One-Way ANOVA, with the LSD Post Hoc Test and Duncan (DMRT), to determine the differences between each treatment group.