Proceedings of the 2nd Borobudur International Symposium on Humanities and Social Sciences, BIS-HSS 2020, 18 November 2020, Magelang, Central Java, Indonesia

Research Article

The Effects of Oral Supplementation of Bitter Melon (Momordica charantia L.) Leaves Extract on the VEGF Serum Level in Diabetic Foot Ulcers: Randomized Controlled Trial

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  • @INPROCEEDINGS{10.4108/eai.18-11-2020.2311791,
        author={Fahrun Nur  Rosyid and Tomy Adi  Prasetyo and Muhtadi  Muhtadi and K Heri Nugroho  HS},
        title={The Effects of Oral Supplementation of Bitter Melon (Momordica charantia L.) Leaves Extract on the VEGF Serum Level in Diabetic Foot Ulcers: Randomized Controlled Trial},
        proceedings={Proceedings of the 2nd Borobudur International Symposium on Humanities and Social Sciences, BIS-HSS 2020, 18 November 2020, Magelang, Central Java, Indonesia},
        publisher={EAI},
        proceedings_a={BIS-HSS},
        year={2021},
        month={9},
        keywords={bitter melon momordica charantia l vegf diabetes mellitus diabetic foot ulcer},
        doi={10.4108/eai.18-11-2020.2311791}
    }
    
  • Fahrun Nur Rosyid
    Tomy Adi Prasetyo
    Muhtadi Muhtadi
    K Heri Nugroho HS
    Year: 2021
    The Effects of Oral Supplementation of Bitter Melon (Momordica charantia L.) Leaves Extract on the VEGF Serum Level in Diabetic Foot Ulcers: Randomized Controlled Trial
    BIS-HSS
    EAI
    DOI: 10.4108/eai.18-11-2020.2311791
Fahrun Nur Rosyid1,*, Tomy Adi Prasetyo1, Muhtadi Muhtadi2, K Heri Nugroho HS3
  • 1: Department of Medical Surgical Nursing, School of Nursing, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia
  • 2: Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia
  • 3: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
*Contact email: fnr100@ums.ac.id

Abstract

The purpose of this study is to determine the effect of oral Bitter Melon (Momordica charantia L.) leaves extract on the serum VEGF level in diabetic foot ulcers. The trial was randomized, double-blinded, and placebo-controlled. Thirty diabetic foot ulcer (DFU) patients with a PEDIS score of 1-8 who met the criteria were divided into two groups: The treatment group received the bitter melon leaves extract orally at a dose of 6 g/day, while the control group received a placebo. The intervention lasted four weeks, and baseline and end-of-treatment VEGF serum levels were determined. The paired t-test and independent t-test were used to analyze the data. After four weeks of treatment, the baseline VEGF serum level in the treatment group decreases from 431.5248.5 to 236.9158 pg/ml (the decline begins at 194.5197.9 pg/ml). Meanwhile, in the control group, the concentration decreases from 382.4351,4 to 191.6121.9 pg/ml (the concentration decreases to 190.8324.9 pg/ml). The effect of oral supplementation with Bitter Melon leaves extract on VEFG serum levels was found to be insignificant (p=0.39). Oral bitter melon leaf extract supplementation was not shown to increase VEFG serum levels in DFU patients.