Proceedings of The 5th Annual International Seminar on Trends in Science and Science Education, AISTSSE 2018, 18-19 October 2018, Medan, Indonesia

Research Article

Effect of Red-Fleshed Pitaya (Hylocereus Polyrhizus) to Increase Gluthatione Peroxidase Levels in Male Rats (Rattus Norvegicus):The Induced Oxidative Stress

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  • @INPROCEEDINGS{10.4108/eai.18-10-2018.2287360,
        author={Novita Sari Harahap and Fajar Apollo Sinaga and Rika  Nailuvar},
        title={Effect of Red-Fleshed Pitaya (Hylocereus Polyrhizus) to Increase Gluthatione Peroxidase Levels in Male Rats (Rattus Norvegicus):The Induced Oxidative Stress},
        proceedings={Proceedings of The 5th Annual International Seminar on Trends in Science and Science Education, AISTSSE 2018, 18-19 October 2018, Medan, Indonesia},
        publisher={EAI},
        proceedings_a={AISTSSE},
        year={2019},
        month={10},
        keywords={oxidative stress glutathione peroxides red-fleshed pitaya rat},
        doi={10.4108/eai.18-10-2018.2287360}
    }
    
  • Novita Sari Harahap
    Fajar Apollo Sinaga
    Rika Nailuvar
    Year: 2019
    Effect of Red-Fleshed Pitaya (Hylocereus Polyrhizus) to Increase Gluthatione Peroxidase Levels in Male Rats (Rattus Norvegicus):The Induced Oxidative Stress
    AISTSSE
    EAI
    DOI: 10.4108/eai.18-10-2018.2287360
Novita Sari Harahap1,*, Fajar Apollo Sinaga2, Rika Nailuvar2
  • 1: Department of Sports Sciences, Faculty of Sports Sciences, Universitas Negeri Medan, Medan, Indonesia
  • 2: Department of Community Medicine/Public Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
*Contact email: novitahrp74@gmail.com

Abstract

High intensity physical activity requires large amounts of antioxidants. Exhausting physical activity can decrease glutathione peroxides levels in response to increasing production of free radicals. Glutathione peroxides levels to eliminated free radicals and reduce oxidative damage. This study aims to know effect antioxidant red-fleshed pitaya extract to increase glutathione peroxides. The subject of this research are 16 male rats, age 3 months with average weight of 200 gr, divided into 2 groups. Group 1 (OS-RFP) : the induced oxidative stress and given aquadest, group 2 (OS+RFP) : the induced oxidative stress and given 100 mg/kgWB of red-fleshed pitaya extract. Oxidative stress is given was swam for 20 minutes, thrice a week for 3 weeks. The glutathione peroxides levels in the group1higher than the group 2. There were significant differences in the increasing glutathione peroxides levels (p=0.000) between group 2 and group 1. This research shows that glutathione peroxides levels have increased in oxidative stress groups given red-fleshed pitaya extract. Red-fleshed pitaya extract has to increase glutathione peroxides levels that is can eliminate oxidative stress.