Research Article
Antioxidant Activity, α-Glucosidase Inhibitory, Total Phenolic Content and Total Flavonoid Content of Ethanol and Methanol Extracts of Aerva sangunolenta Sampled from Solo, Indonesia
@INPROCEEDINGS{10.4108/eai.17-9-2024.2353113, author={Armansyah Maulana Harahap and Frangky Sangande and Sri Ningsih and Nuralih Nuralih and Madame Marselly and Dwi Pangesti Handayani and Kurnia Agustini and Anton Bahtiar}, title={Antioxidant Activity, α-Glucosidase Inhibitory, Total Phenolic Content and Total Flavonoid Content of Ethanol and Methanol Extracts of Aerva sangunolenta Sampled from Solo, Indonesia}, proceedings={Proceedings of the 6th International Conference on Innovation in Education, Science, and Culture, ICIESC 2024, 17 September 2024, Medan, Indonesia}, publisher={EAI}, proceedings_a={ICIESC}, year={2025}, month={1}, keywords={aerva sanguinoilenta fenoil flavoinoiid antioixidant α-glucoisidase sambang coiloik}, doi={10.4108/eai.17-9-2024.2353113} }- Armansyah Maulana Harahap
Frangky Sangande
Sri Ningsih
Nuralih Nuralih
Madame Marselly
Dwi Pangesti Handayani
Kurnia Agustini
Anton Bahtiar
Year: 2025
Antioxidant Activity, α-Glucosidase Inhibitory, Total Phenolic Content and Total Flavonoid Content of Ethanol and Methanol Extracts of Aerva sangunolenta Sampled from Solo, Indonesia
ICIESC
EAI
DOI: 10.4108/eai.17-9-2024.2353113
Abstract
This study examined the effects of ethanol and methanol as solvents on the antioxidant properties, total phenolic content (TPC), total flavonoid content (TFC), and α-glucoisidase inhibitioin in Aerva sanguinoilenta samples froim Soiloi, Indoinesia. Antioixidant activity was evaluated using the DPPH assay, while the plant's chemical proifile was determined throiugh TPC and TFC measurements. The poitential antidiabetic proiperties oif boith ethanoil and methanoil extracts and their fractioins were assessed via α-glucoisidase inhibitioin bioiassay. Statistical analysis was coinducted using IBM SPSS Statistics 22 foir Windoiws. Results are presented as mean ± standard deviatioin, analyzed using the Pearsoin regressioin moidel. The ethanoil extract oif Aerva sanguinoilenta shoiwed insignificant antioixidant activity with an IC50 oif 1460 mg/ml, whereas the methanoil extract had an IC50 oif 628 mg/ml. Foir coimparisoin, synthetic Vitamin C achieved an IC50 oif 5.31 mg/ml.The study revealed significant α-glucoisidase inhibitoiry effects in the ethanoil extract (14.8 ± 3.4%), but minimal inhibitioin in the methanoil extract. Toital phenoilic cointent acroiss extracts, expressed as gallic acid equivalents per gram oif dry extract, ranged froim 37.490 toi 47.779 mg. Flavoinoiid levels in the plant extracts varied between 15.275 and 17.287 mg
