Proceedings of the 2nd International Conference on Law, Social Science, Economics, and Education, ICLSSEE 2022, 16 April 2022, Semarang, Indonesia

Research Article

Formulation and Test of Antibacterial Activity of Antiacne Patch Preparations of Centella Asiatica Leaf Ethanol Extract Against the Growth of Propionibacterium Acnes

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  • @INPROCEEDINGS{10.4108/eai.16-4-2022.2319706,
        author={Nurhikma  Awaluddin and Sri Wahyuni Awaluddin and Akbar  Awaluddin and Ade Irma Suryani},
        title={Formulation and Test of Antibacterial Activity of Antiacne Patch Preparations of Centella Asiatica Leaf Ethanol Extract Against the Growth of Propionibacterium Acnes},
        proceedings={Proceedings of the 2nd International Conference on Law, Social Science, Economics, and Education, ICLSSEE 2022, 16 April 2022, Semarang, Indonesia},
        publisher={EAI},
        proceedings_a={ICLSSEE},
        year={2022},
        month={8},
        keywords={gotu kola leaves patch propionibacterium acnes},
        doi={10.4108/eai.16-4-2022.2319706}
    }
    
  • Nurhikma Awaluddin
    Sri Wahyuni Awaluddin
    Akbar Awaluddin
    Ade Irma Suryani
    Year: 2022
    Formulation and Test of Antibacterial Activity of Antiacne Patch Preparations of Centella Asiatica Leaf Ethanol Extract Against the Growth of Propionibacterium Acnes
    ICLSSEE
    EAI
    DOI: 10.4108/eai.16-4-2022.2319706
Nurhikma Awaluddin1,*, Sri Wahyuni Awaluddin2, Akbar Awaluddin3, Ade Irma Suryani4
  • 1: Faculty Of Pharmacy, Megarezky University Makassar
  • 2: Department of Nursing, Poltekkes Kemenkes Makassar
  • 3: Faculty of Pharmacy, Sekolah Tinggi Farmasi Makassar
  • 4: Faculty of Pharmacy, Megarezky University Makassar
*Contact email: hykma.awaluddin@gmail.com

Abstract

Gotu Kola (Centella Asiatica) is a wild plant that has excellent potential to be used as a medicinal plant because it has antimicrobial activity. The patch is a local preparation that can provide a good therapeutic effect on the skin, and this preparation is an innovation in the drug delivery system. This study aims to know that the ethanol extract of Gotu kola leaves (Centella Asiatica) can be formulated into patch preparations and has the potential to inhibit the growth of Propionibacterium acnes. In this study, Gotu kola extract was formulated in the form of patch dosage with a concentration of 5%, 7%, and 9%. This research design is an experimental type. The method used in testing antibacterial activity is the agar diffusion method and for statistical data analysis using the One-Way ANOVA test method. The results showed that the patch preparation of Gotu kola leaf extract (Centella Asiatica) was physically and chemically stable and the concentration of 9% had the greatest potential in inhibiting the growth of Propionibacterium acnes. It is necessary to do further research on the patch of Gotu kola leaf extract (Centella Asiatica) against other types of bacteria.