Research Article
Impact of Environmental Exposure, Risk factors, Biomarkers in Parkinson’s Disease: A Brief and Comprehensive review
@INPROCEEDINGS{10.4108/eai.13-11-2024.2355677, author={Haribabu T and Archana BG and Manjunatha Panduranga Mudagal and Suresh Janadri and Uday Raj Sharma and Surendra Vada and Nageena Taj and Ranjith Kumar R and Preeti P Angadi and Ranjith Kumar R}, title={Impact of Environmental Exposure, Risk factors, Biomarkers in Parkinson’s Disease: A Brief and Comprehensive review}, proceedings={Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India}, publisher={EAI}, proceedings_a={FPCS}, year={2025}, month={8}, keywords={parkinson’s disease heavy metals pesticides;mptp}, doi={10.4108/eai.13-11-2024.2355677} }- Haribabu T
Archana BG
Manjunatha Panduranga Mudagal
Suresh Janadri
Uday Raj Sharma
Surendra Vada
Nageena Taj
Ranjith Kumar R
Preeti P Angadi
Ranjith Kumar R
Year: 2025
Impact of Environmental Exposure, Risk factors, Biomarkers in Parkinson’s Disease: A Brief and Comprehensive review
FPCS
EAI
DOI: 10.4108/eai.13-11-2024.2355677
Abstract
Parkinson's disease (PD) is defined by the progressive death of nigrostriatal dopaminergic neurons, which is accompanied with intracellular Lewy bodies. The condition is influenced not only by genetic predispositions but also by environmental factors. This paper reviews the pivotal role of environmental exposure risk factors-such as pesticides, heavy metals, solvents, and air pollutants in the development and progression of parkinsonism. It delves into the mechanisms through which these environmental toxins instigate neurodegeneration, exacerbating the underlying pathology. Moreover, the review discusses the emerging significance of biomarkers in assessing environmental exposure levels and predicting individual susceptibility to parkinsonism. Biomarkers offer promise in unravelling the intricate biological processes involved in disease onset and evolution, potentially enabling early detection and intervention strategies. Understanding the intricate interplay between environmental exposures, biomarkers, and parkinsonism is paramount for devising preventive measures and targeted therapeutic interventions.
