Research Article
Design, Synthesis, Antimicrobial, Cyclic Voltammetry and Molecular Docking Studies of L-Methionine founded Schiff bases
@INPROCEEDINGS{10.4108/eai.13-11-2024.2355666, author={Marulasiddeshwara MB and Dakshayani SS and Somashekar MN and Satheesh CE and Golla Ramesh and Shivaraja G and Raghavendra Kumar P}, title={Design, Synthesis, Antimicrobial, Cyclic Voltammetry and Molecular Docking Studies of L-Methionine founded Schiff bases}, proceedings={Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India}, publisher={EAI}, proceedings_a={FPCS}, year={2025}, month={8}, keywords={synthesis schiff base antimicrobial molecular docking studies}, doi={10.4108/eai.13-11-2024.2355666} }- Marulasiddeshwara MB
Dakshayani SS
Somashekar MN
Satheesh CE
Golla Ramesh
Shivaraja G
Raghavendra Kumar P
Year: 2025
Design, Synthesis, Antimicrobial, Cyclic Voltammetry and Molecular Docking Studies of L-Methionine founded Schiff bases
FPCS
EAI
DOI: 10.4108/eai.13-11-2024.2355666
Abstract
By condensing L-2-amino-4-methylthio derived amide, 2 with substituted aldehydes, 5-chloro salicylaldehyde, 5-bromo salicylaldehyde, and orthovanillin resulted a new chiral Schiff bases, 3a-3c. using CHN analysis, polarimetry, spectroscopic studies. The synthesized Schiff bases have been characterised. The antimicrobial assessment of all of the Schiff bases against pathogenic microbial strains proved large antibacterial and antifungal activity with sturdy growth inhibition. The insilico docking studies of Schiff bases inside the active website online of DNA Gyrase (PDB: 3G75) found out favorable binding energies starting from -6.07 to - 7.59 kcal/mol. Additionally, docking with N-Myristoyltransferase (PDB: 1IYL) showed even more potent interactions, with binding energies among -8.9 and -10.2 kcal/mol.
