Research Article
Antioxidant, enzyme kinetics, α-amylase, α-glucosidase inhibition and molecular docking studies of (S,N,O-) type Schiff’s Base and its Pd(II) complex
@INPROCEEDINGS{10.4108/eai.13-11-2024.2355655, author={Venkata Padmaja D and Ramith Ramu and Vishwanatha K and Prithvi S. Shirahatti and Naveen Kumar and Jayashankar B}, title={Antioxidant, enzyme kinetics, α-amylase, α-glucosidase inhibition and molecular docking studies of (S,N,O-) type Schiff’s Base and its Pd(II) complex}, proceedings={Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India}, publisher={EAI}, proceedings_a={FPCS}, year={2025}, month={8}, keywords={schiff’s base pd antioxidant enzyme inhibition molecular docking}, doi={10.4108/eai.13-11-2024.2355655} }- Venkata Padmaja D
Ramith Ramu
Vishwanatha K
Prithvi S. Shirahatti
Naveen Kumar
Jayashankar B
Year: 2025
Antioxidant, enzyme kinetics, α-amylase, α-glucosidase inhibition and molecular docking studies of (S,N,O-) type Schiff’s Base and its Pd(II) complex
FPCS
EAI
DOI: 10.4108/eai.13-11-2024.2355655
Abstract
The antioxidant properties, molecular docking interactions α-glucosidase inhibition, α-amylase, and enzyme kinetics, of (S,N,O-) type Schiff’s base (L) and its complex Pd-L (1) were evaluated. The antioxidant activity was evaluated using various invitro assays, revealing significant free radical scavenging potential. Enzyme kinetics studies were conducted to assess the catalytic efficiency and substrate specificity of the compounds, providing insights into their enzymatic interactions. Furthermore, the α-glucosidase inhibition activity was examined, demonstrating promising inhibitory effects against this enzyme implicated in diabetes management. Molecular docking studies were performed. Overall, these findings highlight the potential of L and Pd-L (1) as multifunctional agents with antioxidant and enzyme inhibitory properties, offering prospects for further exploration in drug development and therapeutic interventions.
