Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Analysis of Plasma Cortisol Level and Salivary Cortisol Level in Chronic Kidney Disease Patients with Depression

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283798,
        author={Arina Widya Murni and Ellyza  Nasrul and Fadrian  Fadrian},
        title={Analysis of  Plasma Cortisol Level and Salivary Cortisol Level in Chronic Kidney Disease Patients with Depression},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={cortisol plasma depression salivary cortisol},
        doi={10.4108/eai.13-11-2018.2283798}
    }
    
  • Arina Widya Murni
    Ellyza Nasrul
    Fadrian Fadrian
    Year: 2019
    Analysis of Plasma Cortisol Level and Salivary Cortisol Level in Chronic Kidney Disease Patients with Depression
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283798
Arina Widya Murni1,*, Ellyza Nasrul2, Fadrian Fadrian3
  • 1: Departement of Internal Medicine Sub division Psychosomatic Medicine
  • 2: Department of Clinical Pathology
  • 3: Department of Internal Medicine Sub Division of Tropical Infection, Faculty of Medicine Universitas Andalas, M. Djamil Hospital, Padang, Indonesia
*Contact email: arina_widya_murni@yahoo.com

Abstract

Chronic Kidney Disease (CKD) had increasing mortality rate every year caused by various causes such as depression. Depression also affects the length of stay, nutritional status and adherence to taking drugs and undergoing hemodialysis. Depression more objectively diagnosing by looking at the value of plasma cortisol levels. Salivary cortisol hormone examination is better because it was non-invasive and more reliable. The aim of this study was to analyze the relationship between plasma cortisol levels and salivary cortisol in chronic kidney disease patients with depression. A cross sectional study, with consecutive sampling was done. There are 50 patient get a blood and saliva sampling, and screening depression with Beck Depression Inventory. Cortisol hormone was check in morning and evening. The data was perform for correlation between cortisol level and stress in two condition morning or evening. The results of this study, there were 50 patients, the mean age of 53.62 ± 13.46 years. The mean level of urea was 172.44 ± 95.47 mg / dL. Mean of creatinine was 9.83 ± 7.06 mg / dL. The mean of morning plasma cortisol level was 62.77 ± 15.81 µg / dL and the mean of afternoon blood cortisol level was 59.82 ± 12.44 µg / dL. The mean of salivary cortisol level is 0.72 ± 1.45 µg / dL. There was a significant correlation between morning plasma cortisol levels with salivary cortisol levels (p = 0.007) in patients with chronic kidney disease with depression.