Research Article
Correlation of Thrombin-Antithrombin Complex With Indoxyl Sulfate Level in Chronic Kidney Disease Patients
@INPROCEEDINGS{10.4108/eai.13-11-2018.2283787, author={Irza Wahid and Nuzirwan Acang and Syaiful Azmi}, title={Correlation of Thrombin-Antithrombin Complex With Indoxyl Sulfate Level in Chronic Kidney Disease Patients}, proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia}, publisher={EAI}, proceedings_a={ICOMHER}, year={2019}, month={5}, keywords={chronic kidney disease indoxyl sulfate tat complex}, doi={10.4108/eai.13-11-2018.2283787} }- Irza Wahid
Nuzirwan Acang
Syaiful Azmi
Year: 2019
Correlation of Thrombin-Antithrombin Complex With Indoxyl Sulfate Level in Chronic Kidney Disease Patients
ICOMHER
EAI
DOI: 10.4108/eai.13-11-2018.2283787
Abstract
Thrombosis is the leading cause of mortality in chronic kidney disease (CKD) patients. The risk of thrombosis in CKD is related to increase of coagulation activity. The Thrombin Antithrombin complex (TAT complex) is a sensitive marker of thrombosis. The mechanism of occurrence of thrombosis in CKD is closely related to indoxyl sulfate uremic toxin. A cross-sectional, analytic observational study conducted in stage 3-5 non-dialysis CKD patients at Dr. M. Djamil Padang Hospital. Of the 30 samples, there was a significant increase (p <0.05) of the mean levels of TAT complex and indoxyl sulfate respectively 12.61 ± 2.49 ng / ml and 4.70 ± 1.96 mg / dl compared to their normal values ( 0.5-10 ng / ml and 1.86 ± 0.30 mg / dl). There was a significant positive correlation between TAT complex and indoxyl sulfate levels (p <0.05; r = 0.52). There was an increase in TAT complex levels in CKD patients which indicated an increase in coagulation/thrombosis activity. Increased levels of indoxyl sulfate in CKD patients indicate the occurrence of accumulation of uremic toxins. The more increasing levels of indoxyl sulfate, the more increases the TAT complex level. The more accumulated the uremic toxin, the more coagulation/thrombosis activity increased. There was a significant increase in the level of TAT complex and indoxyl sulfate, and there was a significant positive correlation with moderate degree of TAT complex with indoxyl sulfate levels in CKD patients.
