Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)

Download277 downloads
  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283708,
        author={Husna  Yetti and Herlina  Herlina and Mayetti  Mayetti and Abdiana  Abdiana and Indra  Ihsan},
        title={CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={cd64 neutrophil sirs sepsis pediatric prognosis},
        doi={10.4108/eai.13-11-2018.2283708}
    }
    
  • Husna Yetti
    Herlina Herlina
    Mayetti Mayetti
    Abdiana Abdiana
    Indra Ihsan
    Year: 2019
    CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283708
Husna Yetti1,*, Herlina Herlina2, Mayetti Mayetti2, Abdiana Abdiana1, Indra Ihsan3
  • 1: Department of Public Health and Community Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia
  • 2: Department of Pediatrics, Faculty of Medicine
  • 3: Andalas University/ M. Djamil General Hospital, Padang, Indonesia
*Contact email: husnayetti@med.unand.ac.id

Abstract

Sepsis is one of the major causes of mortality and morbidity in children. The study aimed to assess the prognostic value and difference of Neutrophil CD64 index regarding sepsis outcome. Methods of this study were a prospective observational study in 62 children with Systemic Inflammatory Response Syndrome (SIRS) were conducted in ER and Pediatric Ward Dr. M. Djamil Hospital, Padang. We collected blood samples to measure Neutrophil CD64 index and blood cultures were drawn to confirm infection. Patients were observed clinically until discharge from the hospital. Based on the clinical course and laboratory test results, patients were categorized as having unproven sepsis, sepsis, septic shock, and nonsurvivor. The average Neutrophil CD64 index were 1.13±0.32; 1.71±0.23; 2.29±0.71; 2.86±1.10 for unproven sepsis, sepsis, septic shock, and nonsurvivors, respectively. The area under the curve (AUC) for hospital mortality was 0.863. At a cut-off level of 1.705 sensitivity was 71.4% and specificity was 72.9%. Patients with CD64 index level higher than 1.705 had 6.7–fold higher probability of dying. The odd ratio is 6.7 (95% CI 1.79-25.27). Neutrophil CD64 was significantly elevated as a severe outcome of sepsis. This result indicates that neutrophil CD64 may be used as a biomarker for predicting mortality.