Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283656,
        author={Qaira  Anum and Eryati  Darwin and Sri  Linuwih and Djong Hon Tjong},
        title={SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={leprosy polymorphism park2 gen snp park2-e01 (-2599)},
        doi={10.4108/eai.13-11-2018.2283656}
    }
    
  • Qaira Anum
    Eryati Darwin
    Sri Linuwih
    Djong Hon Tjong
    Year: 2019
    SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283656
Qaira Anum1,*, Eryati Darwin2, Sri Linuwih3, Djong Hon Tjong4
  • 1: Dermatology and Venereology Departement of Dr. M Djamil Hospital/Medical Faculty of Andalas University, Padang, Indonesia
  • 2: Universitas Andalas, Padang, Indonesia
  • 3: Histology Departement, Faculty of Andalas University, Dermatology and Venereology Departement of Dr. Ciptomangunkusumo Hospital/Medical Faculty of Indonesia University, Jakarta, Indonesia
  • 4: Biology Department, Faculty of Mathematics And Natural Science Andalas University
*Contact email: qairaanuma@yahoo.com

Abstract

Genetic factor is important in determining a person to get leprosy. Genes that affect susceptibility to Mycobacterium Leprae are SNP PARK2-e01 (-2599) PARK2 genes. These genes act as phagocytosis in macrophages in a non-specific immune process. This study aims to prove that there are SNP PARK2-e01 (-2599) PARK2 genes in leprosy and household contact patients. SNP PARK2-e01 (-2599) PARK2 genes were analyzed in 60 individual with leprosy or household contact from West Sumatera. The purpose of this study was to prove the SNP PARK2-e01(-2599) PARK2 gene in leprosy and household contact patients. This research method is observational research with cross-sectional comparative study design, by comparing SNP PARK2-e01 (-2599). The results of this study obtained the most aged in leprosy patients was 12-16 years and household contact aged was 36-45 years (p = 0.293). The leprosy patients group who had SNP PARK2-e01 (-2599) polymorphism PARK2 gene was 90% while in household contact was 83.3%. Statistical test results obtained p = 0.75 with OR = 1.8 (95% CI 0.389-8.323). The conclusion proved he was an SNP PARK2-e01 (-2599) PARK2 gene in leprosy and household contact patients