Research Article
SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy
@INPROCEEDINGS{10.4108/eai.13-11-2018.2283656, author={Qaira Anum and Eryati Darwin and Sri Linuwih and Djong Hon Tjong}, title={SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy}, proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia}, publisher={EAI}, proceedings_a={ICOMHER}, year={2019}, month={5}, keywords={leprosy polymorphism park2 gen snp park2-e01 (-2599)}, doi={10.4108/eai.13-11-2018.2283656} }- Qaira Anum
Eryati Darwin
Sri Linuwih
Djong Hon Tjong
Year: 2019
SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy
ICOMHER
EAI
DOI: 10.4108/eai.13-11-2018.2283656
Abstract
Genetic factor is important in determining a person to get leprosy. Genes that affect susceptibility to Mycobacterium Leprae are SNP PARK2-e01 (-2599) PARK2 genes. These genes act as phagocytosis in macrophages in a non-specific immune process. This study aims to prove that there are SNP PARK2-e01 (-2599) PARK2 genes in leprosy and household contact patients. SNP PARK2-e01 (-2599) PARK2 genes were analyzed in 60 individual with leprosy or household contact from West Sumatera. The purpose of this study was to prove the SNP PARK2-e01(-2599) PARK2 gene in leprosy and household contact patients. This research method is observational research with cross-sectional comparative study design, by comparing SNP PARK2-e01 (-2599). The results of this study obtained the most aged in leprosy patients was 12-16 years and household contact aged was 36-45 years (p = 0.293). The leprosy patients group who had SNP PARK2-e01 (-2599) polymorphism PARK2 gene was 90% while in household contact was 83.3%. Statistical test results obtained p = 0.75 with OR = 1.8 (95% CI 0.389-8.323). The conclusion proved he was an SNP PARK2-e01 (-2599) PARK2 gene in leprosy and household contact patients
