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Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283644,
        author={Masrul  Basyar and Sabrina  Ermayanti},
        title={Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={asthma interleukins respiratory function test},
        doi={10.4108/eai.13-11-2018.2283644}
    }
    
  • Masrul Basyar
    Sabrina Ermayanti
    Year: 2019
    Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283644
Masrul Basyar1,*, Sabrina Ermayanti1
  • 1: Department of Pulmonology and Respiratory Medicine, DR M. Djamil Hospital / Medical Faculty of Universitas Andalas, Padang, Indonesia
*Contact email: parupadang@yahoo.com

Abstract

Asthma is one of the global health issues that occurs in both developed and developing countries. There are a few ways to classify asthma, based on clinical presentation and spirometry, based on immunologic reaction using Interleukin 4 (IL-4), Interleukin 13 (IL-13) and Eosinophil Cationic Protein as chronic respiratory tract inflammation markers. Observational study was held using a cross-sectional design among 46 patients diagnosed with chronic asthma at Dr. M. Djamil General Hospital. Data analysed was using t-test to found relationship between chronic asthma with IL-3 and IL-4. Among 46 patients, 23 samples were mild chronic asthma, 72% of the sample were women (p=0,190), age of the patients with mild chronic asthma was 24,96 years old ± 7,64 year SD, while severe chronic asthma were 29,52 years old±8,88 year (p= 0,232). Interleukin 4 (IL-4) was found less in mild chronic asthma than the severe one, 3,44 (±0,73) pg/ml and 3,64 (±1,11) pg/ml respectively.IL-13 in mild chronic asthma was in the higher level than in the severe ones. The level of IL-4 was 295,23 (±2,38) pg/ml in mild chronic asthma, while the level of IL-13 in severe chronic asthma was less than the mild ones, 294,21 (±3,24) pg/ml. There is no significant relationship between the severity of chronic asthma based on spirometry and level of Interleukin 4. Interleukin 13 was significantly related to chronic asthma

Keywords
asthma interleukins respiratory function test
Published
2019-05-13
Publisher
EAI
http://dx.doi.org/10.4108/eai.13-11-2018.2283644
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