Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283644,
        author={Masrul  Basyar and Sabrina  Ermayanti},
        title={Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={asthma interleukins respiratory function test},
        doi={10.4108/eai.13-11-2018.2283644}
    }
    
  • Masrul Basyar
    Sabrina Ermayanti
    Year: 2019
    Analysis on the Relationship Between Chronic Asthma Based on Spirometry, and Interleukin 4 and Interleukin 13
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283644
Masrul Basyar1,*, Sabrina Ermayanti1
  • 1: Department of Pulmonology and Respiratory Medicine, DR M. Djamil Hospital / Medical Faculty of Universitas Andalas, Padang, Indonesia
*Contact email: parupadang@yahoo.com

Abstract

Asthma is one of the global health issues that occurs in both developed and developing countries. There are a few ways to classify asthma, based on clinical presentation and spirometry, based on immunologic reaction using Interleukin 4 (IL-4), Interleukin 13 (IL-13) and Eosinophil Cationic Protein as chronic respiratory tract inflammation markers. Observational study was held using a cross-sectional design among 46 patients diagnosed with chronic asthma at Dr. M. Djamil General Hospital. Data analysed was using t-test to found relationship between chronic asthma with IL-3 and IL-4. Among 46 patients, 23 samples were mild chronic asthma, 72% of the sample were women (p=0,190), age of the patients with mild chronic asthma was 24,96 years old ± 7,64 year SD, while severe chronic asthma were 29,52 years old±8,88 year (p= 0,232). Interleukin 4 (IL-4) was found less in mild chronic asthma than the severe one, 3,44 (±0,73) pg/ml and 3,64 (±1,11) pg/ml respectively.IL-13 in mild chronic asthma was in the higher level than in the severe ones. The level of IL-4 was 295,23 (±2,38) pg/ml in mild chronic asthma, while the level of IL-13 in severe chronic asthma was less than the mild ones, 294,21 (±3,24) pg/ml. There is no significant relationship between the severity of chronic asthma based on spirometry and level of Interleukin 4. Interleukin 13 was significantly related to chronic asthma