Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Acute Toxicity Study And Antioxidant Activities Of Pohpohan Leaves (Pilea trinervia (Roxb.) Wight) and Kenikir (Cosmos caudatus)

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283642,
        author={Himmi  Marsiati and Susi  Endrini and Arif  Ashari and Fazleen Izzany Abu Bakar and Mohd Fadzelly Abu Bakar},
        title={Acute Toxicity Study And Antioxidant Activities Of Pohpohan Leaves (Pilea trinervia (Roxb.) Wight)  and Kenikir (Cosmos caudatus)},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={acute toxicity study antioxidant activities pohpohan kenikir},
        doi={10.4108/eai.13-11-2018.2283642}
    }
    
  • Himmi Marsiati
    Susi Endrini
    Arif Ashari
    Fazleen Izzany Abu Bakar
    Mohd Fadzelly Abu Bakar
    Year: 2019
    Acute Toxicity Study And Antioxidant Activities Of Pohpohan Leaves (Pilea trinervia (Roxb.) Wight) and Kenikir (Cosmos caudatus)
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283642
Himmi Marsiati1,*, Susi Endrini1, Arif Ashari2, Fazleen Izzany Abu Bakar3, Mohd Fadzelly Abu Bakar3
  • 1: Faculty of Medicine, Universitas YARSI, Jl. Letjend Suprapto Cempaka Putih 10510, Jakarta
  • 2: Herbal Research Centre, Universitas YARSI, Jl. Letjend Suprapto Cempaka Putih 10510, Jakarta
  • 3: Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Hab Pendidikan Tinggi Pagoh, KM1, Jalan Panchor, 84600 Muar, Johor, Malaysia
*Contact email: himmi.marsiati@yarsi.ac.id

Abstract

Kenikir (Cosmos caudatus) and Pohpohan (Pilea trinervia) are widely used as a traditional medicine in Southeast Asia including Indonesia and Malaysia for health benefits purposes. Hence, this research aims to evaluate the antioxidant activity and acute toxicity study of herbal teas from Kenikir dan Pohpohan. The antioxidant activity was conducted using 2,2- diphenyl-1-picrylhydrazyl (DPPH) assay. For the acute toxicity study, a total of 36 rats were divided into 6 groups and administered orally with three different doses of plant extracts (2500, 5000 and 10000 mg/kg body weight for 14 days. The results showed that Cosmos caudatus had higher antioxidant activity than Pilea trinervia with IC50 value of 64 ppm. Meanwhile, for the acute toxicity study, it indicated that both plants extracts teas were not toxic as no mortality was observed after 14 days. Hence, these plants can be developed as pharmaceutical and nutraceutical products for the future