Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

The Correlation between Old-Generation Antiepileptic Drugs Usage with Carotid Intima-Media Thickness in Epilepsy Patient

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283640,
        author={Hendra  Permana and Dedi  Sutia and Restu  Susanti and Umul  Khair},
        title={The Correlation between Old-Generation Antiepileptic Drugs Usage with Carotid Intima-Media Thickness in Epilepsy Patient},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={antiepileptic drug carotid intima-media thickness epilepsy old generation},
        doi={10.4108/eai.13-11-2018.2283640}
    }
    
  • Hendra Permana
    Dedi Sutia
    Restu Susanti
    Umul Khair
    Year: 2019
    The Correlation between Old-Generation Antiepileptic Drugs Usage with Carotid Intima-Media Thickness in Epilepsy Patient
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283640
Hendra Permana1,*, Dedi Sutia1, Restu Susanti1, Umul Khair1
  • 1: Neurology Department, Faculty of Medicine, Universitas Andalas / DR. M.Djamil Hospital, Padang, Indonesia
*Contact email: saint_check_lie@yahoo.com

Abstract

Epilepsy is one of the neurological disorders that quite common, which about 50 million people worldwide affected each year. Most of the epilepsy patients need long-term therapy, and old-generation of antiepileptic is often used as monotherapy. The incidence of atherosclerosis can be estimated by the thickness of tunica intima-media carotid artery. This study aimed to evaluate the correlation between long-term usage of old-generation antiepileptic drugs and the carotid intima-media thickness. We conducted a cross-sectional study in DR. M. Djamil Hospital, Padang, between March until August 2018. A total of 26 epilepsy patients were recruited. Those with the cardiovascular risk factor, the subject who did not undergo treatment regulary were excluded. The carotid intima-media thickness was measured by EPIQ7 Ultrasound systems Machine. The relationship between variables was analyzed using Kendall’s tau test b, and p-value <0.05 was considered to be statistically significant. Most subjects received phenytoin as their regular AED (76.92%), while 4 subjects received Carbamazepine (15.38%) and 1 subject received phenobarbital (3.84%), and the other drugs (3.84%). The mean duration of therapy was 2.88 years. There is no correlation between long-term usage of AEDs and carotid intima-media thickness in epileptic patients (p=0.052). There was no significant correlation between long-term old-generation usage of antiepileptic drug and carotid intima-media thickness