Analysis of Correlation between Interleukin-6 Gastric Mucosa with Plasma Cortisol Level in Functional Dyspepsia with Psychological Stress

Pathophysiology of Functional dyspepsia still unclear, many factors had been a contribution. Cortisol was hormone stress that releases from cortex adrenal through activation of the Hypothalamus-Pituitary-Adrenal Axis (HPA axis). It could affect immunity in the gastrointestinal mucosa and affected of IL-6 expression. This study aimed to determine the correlation of expression IL-6 in gastric mucosa with cortisol level in patients with functional dyspepsia with stress. It was a cross-sectional study with consecutive sampling method. There are 80 patient got a blood sampling, endoscopic and mucosal biopsy — screening stress with DASS 42. Morning and evening Cortisol plasma was examined with Elysa, immunohistochemical methods examined IL-6. 80 patients meet the criteria, divided in to stress group and non-stress group with the range of age 18-65 years. The mean value of morning cortisol was 15,79 ±7,6.µg / dL and evening cortisol was 6,43±4,53 µg / dL at group with no stress. In group with stress the cortisol morning was 24,03±12,18 µg / dL and cortisol evening was 12,42±9,25 µg / dL. Mean value of expression of IL-6 In gastric mucosa was 72,95±19,49 in the stress group and 73,28±16,70 in the non-stress group There was a significant correlation between morning plasma cortisol with expression IL-6 in the stress group (p = 0,05) and no significant result in the non-stress group