Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Analysis of Correlation between Interleukin-6 Gastric Mucosa with Plasma Cortisol Level in Functional Dyspepsia with Psychological Stress

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283530,
        author={Arina Widya Murni and Nita Afriani},
        title={Analysis of  Correlation between Interleukin-6 Gastric Mucosa with Plasma Cortisol Level in Functional Dyspepsia with Psychological Stress},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={cortisol plasma expression il-6 psychological stress},
        doi={10.4108/eai.13-11-2018.2283530}
    }
    
  • Arina Widya Murni
    Nita Afriani
    Year: 2019
    Analysis of Correlation between Interleukin-6 Gastric Mucosa with Plasma Cortisol Level in Functional Dyspepsia with Psychological Stress
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283530
Arina Widya Murni1,*, Nita Afriani1
  • 1: Department of Internal Medicine Subdivision Gastroenterohepatology Medicine, Faculty of Medicine, Universitas Andalas
*Contact email: arinawidyamurni@med.unand.ac.id

Abstract

Pathophysiology of Functional dyspepsia still unclear, many factors had been a contribution. Cortisol was hormone stress that releases from cortex adrenal through activation of the Hypothalamus-Pituitary-Adrenal Axis (HPA axis). It could affect immunity in the gastrointestinal mucosa and affected of IL-6 expression. This study aimed to determine the correlation of expression IL-6 in gastric mucosa with cortisol level in patients with functional dyspepsia with stress. It was a cross-sectional study with consecutive sampling method. There are 80 patient got a blood sampling, endoscopic and mucosal biopsy — screening stress with DASS 42. Morning and evening Cortisol plasma was examined with Elysa, immunohistochemical methods examined IL-6. 80 patients meet the criteria, divided in to stress group and non-stress group with the range of age 18-65 years. The mean value of morning cortisol was 15,79 ±7,6.µg / dL and evening cortisol was 6,43±4,53 µg / dL at group with no stress. In group with stress the cortisol morning was 24,03±12,18 µg / dL and cortisol evening was 12,42±9,25 µg / dL. Mean value of expression of IL-6 In gastric mucosa was 72,95±19,49 in the stress group and 73,28±16,70 in the non-stress group There was a significant correlation between morning plasma cortisol with expression IL-6 in the stress group (p = 0,05) and no significant result in the non-stress group