Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Nano Curcumin Effect For Kidney Fibrotic Caused By Unilateral Ureter Obstruction Based On Expression Matrix Metalloproteinase-9

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283528,
        author={Alvarino  Alvarino and Yanwirasti  Yanwirasti},
        title={Nano Curcumin Effect For Kidney Fibrotic Caused By Unilateral Ureter Obstruction Based On Expression Matrix Metalloproteinase-9},
        proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
        publisher={EAI},
        proceedings_a={ICOMHER},
        year={2019},
        month={5},
        keywords={kidney fibrosis mmp-9 nano curcumin},
        doi={10.4108/eai.13-11-2018.2283528}
    }
    
  • Alvarino Alvarino
    Yanwirasti Yanwirasti
    Year: 2019
    Nano Curcumin Effect For Kidney Fibrotic Caused By Unilateral Ureter Obstruction Based On Expression Matrix Metalloproteinase-9
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283528
Alvarino Alvarino1,*, Yanwirasti Yanwirasti2
  • 1: Department of Surgery, Division of Urology, M. Djamil Hospital/Faculty of Medicine, Universitas Andalas, Padang, Indonesia
  • 2: Department of Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
*Contact email: alvarinouro@yahoo.com

Abstract

Upper urinary tract obstruction is a such a problem in urology which can occur in any phase of human life and can occur along the upper urinary tract. This condition can lead to hydronephrosis. It can make glomerular endothelial dysfunction and change kidney structure such as interstitial fibrotic, tubular atrophy and apoptosis and also intestinal inflammation. Curcumin is one of the bioactive compounds from temulawak (Curcuma xanthorhiza Roxb) and turmeric (Curcuma longa) which is expected to resolve fibrotic. This was an experimental study with post test control group design in 34 adult male wistar rats aged 10-12 weeks were tied unilateral ureter. The statistical tests using t-test shows significant differences (p< 0.05) in that a variable. The group of rats without administration of nano curcumin also has more fibrosis area with score 4 (>81%) about 64,7%, whereas the group of rats which given nanocurcumin has fibrosis area score 3(51%-80%) about 52,9%. The statistical tests using Mann-Whitney show a significant difference (p<0.05). TGF-β1 is the main stimulator of fibroblast activation. Curcumin supplementation was significantly reduced fibrosis. In order hand, different curcumin concentration was inhibited by NRK-49F and stimulated by TGF-β1. Nano curcumin can suppress the expression of MMP-9 and the extent of renal fibrosis in rats with unilateral ureteral obstruction