Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia

Research Article

Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria

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  • @INPROCEEDINGS{10.4108/eai.13-11-2018.2283525,
    author={Adrial Adrial and Ellyza Nasrul and Rosfita Rasyid},
    title={Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria},
    proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia},
    publisher={EAI},
    proceedings_a={ICOMHER},
    year={2019},
    month={5},
    keywords={malaria salivary glands transmission-blocking vaccine anopheles sundaicus parasitemia density},
    doi={10.4108/eai.13-11-2018.2283525}
}
  • Adrial Adrial
    Ellyza Nasrul
    Rosfita Rasyid
    Year: 2019
    Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria
    ICOMHER
    EAI
    DOI: 10.4108/eai.13-11-2018.2283525
Adrial Adrial1,*, Ellyza Nasrul2, Rosfita Rasyid3
  • 1: Department of Parasitology, Faculty of Medicine, Universitas Andalas Padang, Indonesia
  • 2: Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas Padang, Indonesia
  • 3: Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Andalas Padang, Indonesia
*Contact email: adrial@med.unand.ac.id

Abstract

This study aimed to determine parasitemia density of white mice vaccinated of Anopheles sundaicus (An. sundaicus) salivary gland extract and infected with Plasmodium berghei as a model in fighting malaria This study used experimental study design. This study samples 45 BALB/ c mice aged 6-8 weeks consisted of three groups: control group (C): vaccinated with Phosphate Buffer Saline (PBS) mixed with adjuvant (IFA and CFA). Pellet group (P): vaccinated with pellets extract of An. sundaicus salivary glands mixed with adjuvant (IFA and CFA). Supernatan group (S): vaccinated with supernatant extracts of An. sundaicus salivary glands mixed with adjuvant (IFA and CFA). Data analysis using one-way anova. A two-tailed P-value of <0.05 was considered statistically significant. Data analysis was carried out in Stata version 14.2 (Stata Corporation). The results are are known parasitemia density was 8.81% for the control group, 7.02% for the pellet extract group and 3.35% for the supernatant extract group. The results of ANOVA statistical analysis obtained showed no significant differences (P> 0.05) from the three treatment groups: the control group, pellet extract, and extract of the salivary gland supernatant. sundaicus. The results of this study concluded that the administration of supernatant extract and pellet extract of Anopheles sundaicus salivary glands was able to reduce the density of Plasmodium berghei parasitemia

Keywords
malaria salivary glands transmission-blocking vaccine anopheles sundaicus parasitemia density
Published
2019-05-13
Publisher
EAI
http://dx.doi.org/10.4108/eai.13-11-2018.2283525
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