Research Article
Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria
@INPROCEEDINGS{10.4108/eai.13-11-2018.2283525, author={Adrial Adrial and Ellyza Nasrul and Rosfita Rasyid}, title={Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria}, proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia}, publisher={EAI}, proceedings_a={ICOMHER}, year={2019}, month={5}, keywords={malaria salivary glands transmission-blocking vaccine anopheles sundaicus parasitemia density}, doi={10.4108/eai.13-11-2018.2283525} }- Adrial Adrial
Ellyza Nasrul
Rosfita Rasyid
Year: 2019
Parasitemia Density Of White Mice Vaccinated of Anopheles Sundaicus Salivary Gland Extract And Plasmodium Berghei Infected As A Model In Fighting Malaria
ICOMHER
EAI
DOI: 10.4108/eai.13-11-2018.2283525
Abstract
This study aimed to determine parasitemia density of white mice vaccinated of Anopheles sundaicus (An. sundaicus) salivary gland extract and infected with Plasmodium berghei as a model in fighting malaria This study used experimental study design. This study samples 45 BALB/ c mice aged 6-8 weeks consisted of three groups: control group (C): vaccinated with Phosphate Buffer Saline (PBS) mixed with adjuvant (IFA and CFA). Pellet group (P): vaccinated with pellets extract of An. sundaicus salivary glands mixed with adjuvant (IFA and CFA). Supernatan group (S): vaccinated with supernatant extracts of An. sundaicus salivary glands mixed with adjuvant (IFA and CFA). Data analysis using one-way anova. A two-tailed P-value of <0.05 was considered statistically significant. Data analysis was carried out in Stata version 14.2 (Stata Corporation). The results are are known parasitemia density was 8.81% for the control group, 7.02% for the pellet extract group and 3.35% for the supernatant extract group. The results of ANOVA statistical analysis obtained showed no significant differences (P> 0.05) from the three treatment groups: the control group, pellet extract, and extract of the salivary gland supernatant. sundaicus. The results of this study concluded that the administration of supernatant extract and pellet extract of Anopheles sundaicus salivary glands was able to reduce the density of Plasmodium berghei parasitemia
