1st International ICST Conference on Bio Inspired Models of Network, Information and Computing Systems

Research Article

Logical nano-computation in enzymatic reaction networks

  • @INPROCEEDINGS{10.1145/1315843.1315852,
        author={Martin  Stetter and Bernd Schurmann and Michael  Hofstetter},
        title={Logical nano-computation in enzymatic reaction networks},
        proceedings={1st International ICST Conference on Bio Inspired Models of Network, Information and Computing Systems},
        publisher={ACM},
        proceedings_a={BIONETICS},
        year={2006},
        month={12},
        keywords={},
        doi={10.1145/1315843.1315852}
    }
    
  • Martin Stetter
    Bernd Schurmann
    Michael Hofstetter
    Year: 2006
    Logical nano-computation in enzymatic reaction networks
    BIONETICS
    ACM
    DOI: 10.1145/1315843.1315852
Martin Stetter1,*, Bernd Schurmann1,*, Michael Hofstetter2,*
  • 1: Siemens Corporate Technology, Information & Communications, 81730 Munich, Germany
  • 2: Siemens Corporate Technology Information & Communications, 81730 Munich, Germany and Institute of Biophysics, University of Regensburg, 93040 Regensburg, Germany
*Contact email: stetter@siemens.com, b.schuermann@siemens.com, michaelhofstetter@hotmail.com

Abstract

We propose a way to implement logical operations at the nanoscale by means of enzymatic reaction networks such as kinase-phosphatase networks. For this we suggest and analyze a small recurrent enzymatic reaction network with only four molecule species which contains a positive and a double negative feedback loop. The system is shown to have bistable regimes, the phase boundaries of which are analytically determined. We show that, by adjustment of the total concentrations of the species relative to the range of concentrations of the input substances, it is possible to flexibly implement logical AND, OR, and NOT gates with variable input sensitivity and output dynamic range. Finally, a realistic kinase-phosphatase implementation of the circuit is provided.