Bio-Inspired Models of Network, Information, and Computing Systems. 5th International ICST Conference, BIONETICS 2010, Boston, USA, December 1-3, 2010, Revised Selected Papers

Research Article

A Checkpoint-Orientated Modelling for Cell Cycle Simulation

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  • @INPROCEEDINGS{10.1007/978-3-642-32615-8_6,
        author={Jonathan Pascalie and Herv\^{e} Luga and Val\^{e}rie Lobjois and Bernard Ducommun and Yves Duthen},
        title={A Checkpoint-Orientated Modelling for Cell Cycle Simulation},
        proceedings={Bio-Inspired Models of Network, Information, and Computing Systems. 5th International ICST Conference, BIONETICS 2010, Boston, USA, December 1-3, 2010, Revised Selected Papers},
        proceedings_a={BIONETICS},
        year={2012},
        month={10},
        keywords={artificial life cell simulation oncogenesis cell cycle},
        doi={10.1007/978-3-642-32615-8_6}
    }
    
  • Jonathan Pascalie
    Hervé Luga
    Valérie Lobjois
    Bernard Ducommun
    Yves Duthen
    Year: 2012
    A Checkpoint-Orientated Modelling for Cell Cycle Simulation
    BIONETICS
    Springer
    DOI: 10.1007/978-3-642-32615-8_6
Jonathan Pascalie1,*, Hervé Luga1,*, Valérie Lobjois2,*, Bernard Ducommun2,*, Yves Duthen1,*
  • 1: IRIT - UMR5505 - University of Toulouse
  • 2: ITAV - CNRS - University of Toulouse
*Contact email: jonathan.pascalie@irit.fr, herve.luga@irit.fr, valerie.lobjois@itav-recherche.fr, bernard.ducommun@itav-recherche.fr, yves.duthen@irit.fr

Abstract

In this paper we propose a new model of cell cycle simulator which will be used to analyse checkpoint response in multicellular tumor spheroids. Whereas most of the models are phase orientated, our model integrates environmental parameters and checkpoint responses that are required to control cell cycle progression. We will present in this paper our work under progress and the different experiments to be performed in order to validate our cell cycle simulator.