Quantitative Analysis of the Feedback of the Robust Signaling Pathway Network of Myosin V Molecular Motors on GluR1 of AMPA in Neurons: A Networking Approach for Controlling Nanobiomachines

Jian-Qin Liu; Tadashi Nakano

Nano-Net. 4th International ICST Conference, Nano-Net 2009, Lucerne, Switzerland, October 18-20, 2009. Proceedings

Research Article

Quantitative Analysis of the Feedback of the Robust Signaling Pathway Network of Myosin V Molecular Motors on GluR1 of AMPA in Neurons: A Networking Approach for Controlling Nanobiomachines

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@INPROCEEDINGS{10.1007/978-3-642-04850-0_5,
    author={Jian-Qin Liu and Tadashi Nakano},
    title={Quantitative Analysis of the Feedback of the Robust Signaling Pathway Network of Myosin V Molecular Motors on GluR1 of AMPA in Neurons: A Networking Approach for Controlling Nanobiomachines},
    proceedings={Nano-Net. 4th International ICST Conference, Nano-Net 2009, Lucerne, Switzerland, October 18-20, 2009. Proceedings},
    proceedings_a={NANO-NET},
    year={2012},
    month={5},
    keywords={Signaling Pathway Network Nanobiomachine Molecular Motor},
    doi={10.1007/978-3-642-04850-0_5}
}

Jian-Qin Liu
Tadashi Nakano
Year: 2012
Quantitative Analysis of the Feedback of the Robust Signaling Pathway Network of Myosin V Molecular Motors on GluR1 of AMPA in Neurons: A Networking Approach for Controlling Nanobiomachines
NANO-NET
Springer
DOI: 10.1007/978-3-642-04850-0_5

Jian-Qin Liu¹^,*, Tadashi Nakano²^,*

1: National Institute of Information and Communications Technology
2: Osaka University

*Contact email: liu@nict.go.jp, tnakano@wakate.frc.eng.osaka-u.ac.jp

Abstract

Acting as nanobiomachines within the cell, myosin V molecular motors contribute greatly to the LTP (Long Term Potentiation) in neural signaling, which transport the recycling endosomes from the dendrite to the spine of neurons and the GluR1 in AMPA receptors lead to the activities of memorization in brains. However it is unknown that how the restriction of GluR1 at the spine of neuron is caused by the signaling cascade of myosin V and Rab11/Rab11-FIP2 during the myosin V centered signaling process in neurons. Here we report that the feedback of the biochemical reaction for binding Myosin V and Rab11/Rab11-FIP2 plays a pivotal role to restrict the accumulation of GluR1 at the spine. We have investigated the feedback of myosin V and Rab11/Rab11-FIP2 on the convergence of GluR1 by using the computational model of intracellular signaling pathway networks we designed and the simulation software Cell Illustrator Professional Version 3.0 ®. The obtained results show that controllability of molecular motor based nanobiomachines is inevitable for exploring the molecular mechanism of neuroscience at the nanoscale.

Keywords: Signaling Pathway Network Nanobiomachine Molecular Motor

Published: 2012-05-28

: http://dx.doi.org/10.1007/978-3-642-04850-0_5