4th International ICST Workshop on Nano-bio-sensing

Research Article

Quantum Dots and Wires to Improve Enzymes-Based Electrochemical Bio-sensing

  • @INPROCEEDINGS{10.1007/978-3-642-04850-0_26,
        author={Sandro Carrara and Cristina Boero and Giovanni Micheli},
        title={Quantum Dots and Wires to Improve Enzymes-Based Electrochemical Bio-sensing},
        proceedings={4th International ICST Workshop on Nano-bio-sensing},
        keywords={Quantum Dots Quantum Wires Gold Nano-Particles Carbon Nanotubes Oxidases Cytochromes Electrochemical detection},
  • Sandro Carrara
    Cristina Boero
    Giovanni Micheli
    Year: 2012
    Quantum Dots and Wires to Improve Enzymes-Based Electrochemical Bio-sensing
    DOI: 10.1007/978-3-642-04850-0_26
Sandro Carrara1,*, Cristina Boero1, Giovanni Micheli1
  • 1: EPFL, Swiss Federal Institute of Technology, Lausanne, EPFL IC ISIM LSI1, INF 338 (Bâtiment INF)
*Contact email: sandro.carrara@epfl.ch


An investigation on nano-structured electrodes to detect different metabolites is proposed in this paper. Three different metabolites are considered: glucose, lactate, and cholesterol. The direct detection of hydrogen peroxide is also considered since it does not involve any enzyme. The metabolites and the peroxide were detected by using screen-printed electrodes modified by using multi-walled carbon nanotubes. In all cases, improvements of orders of magnitude were registered both on detection sensitivity and on detection limit. A close comparison with data recently published in literature has shown the existence of an inverse linear correlation between detection sensitivity and detection limit when sensor performances improve due to nano-structured materials. This inverse linear relationship seems to be a general law as it is here demonstrated for all the considered detections on glucose, lactate, cholesterol, and hydrogen peroxide.