Complex Sciences. First International Conference, Complex 2009, Shanghai, China, February 23-25, 2009. Revised Papers, Part 1

Research Article

Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by

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  • @INPROCEEDINGS{10.1007/978-3-642-02466-5_44,
        author={Jianxiong Ye and Enmin Feng and Lei Wang and Zhilong Xiu and Yaqin Sun},
        title={Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by 
                },
        proceedings={Complex Sciences. First International Conference, Complex 2009, Shanghai, China, February 23-25, 2009. Revised Papers, Part 1},
        proceedings_a={COMPLEX PART 1},
        year={2012},
        month={5},
        keywords={Metabolic network inference Biological robustness Transport across cell membrane Parameter identification},
        doi={10.1007/978-3-642-02466-5_44}
    }
    
  • Jianxiong Ye
    Enmin Feng
    Lei Wang
    Zhilong Xiu
    Yaqin Sun
    Year: 2012
    Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by
    COMPLEX PART 1
    Springer
    DOI: 10.1007/978-3-642-02466-5_44
Jianxiong Ye1,*, Enmin Feng1, Lei Wang1, Zhilong Xiu1, Yaqin Sun1
  • 1: Dalian University of Technology
*Contact email: yejianxiong128@yahoo.cn

Abstract

Glycerol bioconversion to 1,3-propanediol (1,3-PD) by () can be characterized by an intricate network of interactions among biochemical fluxes, metabolic compounds, key enzymes and genetic regulatory. To date, there still exist some uncertain factors in this complex network because of the limitation in bio-techniques, especially in measuring techniques for intracellular substances. In this paper, among these uncertain factors, we aim to infer the transport mechanisms of glycerol and 1,3-PD across the cell membrane, which have received intensive interest in recent years. On the basis of different inferences of the transport mechanisms, we reconstruct various metabolic networks correspondingly and subsequently develop their dynamical systems (S-systems). To determine the most reasonable metabolic network from all possible ones, we establish a quantitative definition of biological robustness and undertake parameter identification and robustness analysis for each system. Numerical results show that it is most possible that both glycerol and 1,3-PD pass the cell membrane by active transport and passive diffusion.