Research Article
Peripheral Nerve Injuries: Impact, Solutions and Innovation
@INPROCEEDINGS{10.1007/978-3-032-38657-1_11, author={Antonio Coviello and Giulio Franceschini and Davide Scazzoli and Manuela Crocco and Silvia Mura and Paolo Motto Ros and Danilo Demarchi and Federica Burinato and Anna Simeone and Virginia Tasso and Chiara Cavigliano and Andrea Cerutti and Yeshua Giacalone and Umberto Spagnolini and Maurizio Magarini}, title={Peripheral Nerve Injuries: Impact, Solutions and Innovation}, proceedings={Body Area Networks. 20th EAI International Conference, BodyNets 2025, Okayama, Japan, December 2--4, 2025, Proceedings}, proceedings_a={BODYNETS}, year={2026}, month={10}, keywords={Peripheral Nerve Injuries Implantable Device Stakeholder Engagement Functional Bypass}, doi={10.1007/978-3-032-38657-1_11} }- Antonio Coviello
Giulio Franceschini
Davide Scazzoli
Manuela Crocco
Silvia Mura
Paolo Motto Ros
Danilo Demarchi
Federica Burinato
Anna Simeone
Virginia Tasso
Chiara Cavigliano
Andrea Cerutti
Yeshua Giacalone
Umberto Spagnolini
Maurizio Magarini
Year: 2026
Peripheral Nerve Injuries: Impact, Solutions and Innovation
BODYNETS
Springer
DOI: 10.1007/978-3-032-38657-1_11
Abstract
Peripheral nerve injuries (PNIs) remain a significant clinical challenge, impacting both patients’ quality of life and healthcare systems globally. This paper examines the individual and societal burdens of PNIs, reviewing current therapeutic strategies, including pharmacology, neuromodulation, surgery, and rehabilitation. Despite advancements, these approaches often fail to restore complex nerve functions, particularly in severe cases. We propose a novel implantable system that bypasses nerve lesions by recording neural activity proximally, processing the signals externally, and delivering precise stimulation distally. The system integrates multi-contact cuffs for both sensing and stimulation, ensuring minimal invasiveness and enhanced safety. We present a detailed analysis of the system’s signal processing techniques, including noise reduction and feature extraction, and its potential for motor and sensory restoration. Furthermore, we explore the translational path for this technology, focusing on clinical trials, regulatory approval, and stakeholder alignment, including patients, clinicians, manufacturers, and payers. This solution aims to bridge existing gaps in PNI treatment by providing a functional bypass that restores nerve function while reducing long-term healthcare costs.