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Simulation Tools and Techniques. 13th EAI International Conference, SIMUtools 2021, Virtual Event, November 5-6, 2021, Proceedings

Research Article

Prediction Protein-Protein Interactions with LSTM

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  • @INPROCEEDINGS{10.1007/978-3-030-97124-3_41,
        author={Zheng Tao and Jiahao Yao and Chao Yuan and Ning Zhao and Bin Yang and Baitong Chen and Wenzheng Bao},
        title={Prediction Protein-Protein Interactions with LSTM},
        proceedings={Simulation Tools and Techniques. 13th EAI International Conference, SIMUtools 2021, Virtual Event, November 5-6, 2021, Proceedings},
        proceedings_a={SIMUTOOLS},
        year={2022},
        month={3},
        keywords={Deep learning Protein-protein interaction LSTM},
        doi={10.1007/978-3-030-97124-3_41}
    }
    
  • Zheng Tao
    Jiahao Yao
    Chao Yuan
    Ning Zhao
    Bin Yang
    Baitong Chen
    Wenzheng Bao
    Year: 2022
    Prediction Protein-Protein Interactions with LSTM
    SIMUTOOLS
    Springer
    DOI: 10.1007/978-3-030-97124-3_41
Zheng Tao1, Jiahao Yao1, Chao Yuan1, Ning Zhao1, Bin Yang2, Baitong Chen3, Wenzheng Bao1
  • 1: School of Information Engineering, Xuzhou University of Technology
  • 2: School of Information Science and Engineering, Zaozhuang University
  • 3: Xuzhou No. 1 People’s Hospital

Abstract

As the basis and key of cell activities, protein plays an important role in many life activities. Protein usually does not work alone. Under normal circumstances, most proteins perform specific functions by interacting with other proteins, and play the greatest role in life activity. The prediction of protein-protein interaction (PPI) is a very basic and important research in bioinformatics. PPI controls a large number of cell activities and is the basis of most cell activities. It provides a very important theoretical basis and support for disease prevention and treatment, and drug development. Because experimental methods are slow and expensive, methods based on machine learning are gradually being applied to PPI problems. We propose a new model called BiLSTM-RF, which can effectively predict PPI.

Keywords
Deep learning Protein-protein interaction LSTM
Published
2022-03-31
Appears in
SpringerLink
http://dx.doi.org/10.1007/978-3-030-97124-3_41
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