A Checkpoint-Orientated Modelling for Cell Cycle Simulation

Jonathan Pascalie; Hervé Luga; Valérie Lobjois; Bernard Ducommun; Yves Duthen

Bio-Inspired Models of Network, Information, and Computing Systems. 5th International ICST Conference, BIONETICS 2010, Boston, USA, December 1-3, 2010, Revised Selected Papers

Research Article

A Checkpoint-Orientated Modelling for Cell Cycle Simulation

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@INPROCEEDINGS{10.1007/978-3-642-32615-8_6,
    author={Jonathan Pascalie and Herv\^{e} Luga and Val\^{e}rie Lobjois and Bernard Ducommun and Yves Duthen},
    title={A Checkpoint-Orientated Modelling for Cell Cycle Simulation},
    proceedings={Bio-Inspired Models of Network, Information, and Computing Systems. 5th International ICST Conference, BIONETICS 2010, Boston, USA, December 1-3, 2010, Revised Selected Papers},
    proceedings_a={BIONETICS},
    year={2012},
    month={10},
    keywords={artificial life cell simulation oncogenesis cell cycle},
    doi={10.1007/978-3-642-32615-8_6}
}

Jonathan Pascalie
Hervé Luga
Valérie Lobjois
Bernard Ducommun
Yves Duthen
Year: 2012
A Checkpoint-Orientated Modelling for Cell Cycle Simulation
BIONETICS
Springer
DOI: 10.1007/978-3-642-32615-8_6

Jonathan Pascalie¹^,*, Hervé Luga¹^,*, Valérie Lobjois²^,*, Bernard Ducommun²^,*, Yves Duthen¹^,*

1: IRIT - UMR5505 - University of Toulouse
2: ITAV - CNRS - University of Toulouse

*Contact email: jonathan.pascalie@irit.fr, herve.luga@irit.fr, valerie.lobjois@itav-recherche.fr, bernard.ducommun@itav-recherche.fr, yves.duthen@irit.fr

Abstract

In this paper we propose a new model of cell cycle simulator which will be used to analyse checkpoint response in multicellular tumor spheroids. Whereas most of the models are phase orientated, our model integrates environmental parameters and checkpoint responses that are required to control cell cycle progression. We will present in this paper our work under progress and the different experiments to be performed in order to validate our cell cycle simulator.

Keywords: artificial life cell simulation oncogenesis cell cycle

Published: 2012-10-18

: http://dx.doi.org/10.1007/978-3-642-32615-8_6