Research Article
A Filter for the Cooperative Kinase Network of Budding Yeast
@INPROCEEDINGS{10.1007/978-3-642-32615-8_55, author={Jian-Qin Liu and Tadashi Nakano}, title={A Filter for the Cooperative Kinase Network of Budding Yeast }, proceedings={Bio-Inspired Models of Network, Information, and Computing Systems. 5th International ICST Conference, BIONETICS 2010, Boston, USA, December 1-3, 2010, Revised Selected Papers}, proceedings_a={BIONETICS}, year={2012}, month={10}, keywords={Signaling pathway kinase MAPK cascade bioinformatics}, doi={10.1007/978-3-642-32615-8_55} }- Jian-Qin Liu
Tadashi Nakano
Year: 2012
A Filter for the Cooperative Kinase Network of Budding Yeast
BIONETICS
Springer
DOI: 10.1007/978-3-642-32615-8_55
Abstract
In the cooperative kinase network, a kinase interacts with other kinases for sustaining cellular signaling processes that greatly influence the major functions of cells. Here a key question is how the interacting kinases form a filtering network to estimate the original signal in the presence of stochastic fluctuation caused by the interactions. In this short paper, a filter is designed to estimate the concentration of the molecular signal Ste20 of the MAPK (mitogen-activated protein kinase) cascade in budding yeast based on the Ste20-Ste11-Ste7 pathway, in which kinases interact with each other. The filter is tested in simulations and the result shows that the estimated signal can be used to recognize the original signal. It is concluded that the Ste20-Ste11-Ste7 pathway can be regulated to analyze cell cycle processes through the interactions among kinases in the MAPK cascade.
